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LMO2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647939

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately… More details

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Product Overview

Online Datasheet in PDF
Product Name
LMO2, Polyclonal Antibody
Full Product Name
LMO2, NT (LMO2, RBTN2, RBTNL1, RHOM2, TTG2, Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2)
Product Gene Name
anti-LMO2 antibody
Product Synonym Names
Anti -LMO2, NT (LMO2, RBTN2, RBTNL1, RHOM2, TTG2, Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,358 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (33880122..33913836, complement). Location: 11p13
OMIM
180385
3D Structure
ModBase 3D Structure for P25791
Immunogen
LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LMO2.

Product Categories/Family for anti-LMO2 antibody

Antibodies; Abs to Amino Acids
Applications Tested/Suitable for anti-LMO2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LMO2 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-LMO2 antibody

LMO2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the LMO2 antibody detected the LMO2 protein (arrow).
Rabbit Anti-LMO2 Polyclonal Antibody – Cat# MBS647939

Immunohistochemistry (IHC) of anti-LMO2 antibody

LMO2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LMO2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-LMO2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647939

Other Notes

Small volumes of anti-LMO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LMO2 purchase

MBS647939 is an antibody targeting LMO2. Also known as LMO2, NT (LMO2, RBTN2, RBTNL1, RHOM2, TTG2, Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LMO2. It may not necessarily be applicable to this product.

NCBI GI #
49256403
NCBI GeneID
4005
NCBI Accession #
AAH73973.1
UniProt Primary Accession #
P25791
UniProt Secondary Accession #
Q9HD58
UniProt Related Accession #
P25791
NCBI Official Full Name
LMO2 protein
NCBI Official Synonym Full Names
LIM domain only 2 (rhombotin-like 1)
NCBI Official Symbol
LMO2
NCBI Official Synonym Symbols
TTG2; RBTN2; RHOM2; RBTNL1
UniProt Protein Name
Rhombotin-2
UniProt Synonym Protein Names
Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2
Protein Family
Rhombotin
UniProt Gene Name
LMO2
UniProt Synonym Gene Names
RBTN2; RBTNL1; RHOM2; TTG2; LMO-2
UniProt Entry Name
RBTN2_HUMAN
NCBI Protein Information
rhombotin-2; LMO-2; rhombotin 2; rhombotin-like 1; LIM domain only protein 2; T-cell translocation gene 2; cysteine-rich protein TTG-2; T-cell translocation protein 2

UniProt Comments for LMO2

Function: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Subunit structure: Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL

By similarity. Interacts with BEX2 and KDM5A. Ref.4 Ref.5

Subcellular location: Nucleus

Potential.

Domain: The second LIM zinc-binding domain interacts with KDM5A.

Involvement in disease: A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Sequence similarities: Contains 2 LIM zinc-binding domains.

Sequence caution: The sequence AAF98804.1 differs from that shown. Reason: Intron retention.The sequence AAH73973.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.The sequence CAA43430.1 differs from that shown. Reason: Frameshift at several positions.
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Research Articles on LMO2

1. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LMO2 antibody

 Reference Product  PubMed Publications
 TAL1 antibody  >107 publications with LMO2 and TAL1
 LDB1 antibody  >55 publications with LMO2 and LDB1
 GATA1 antibody  >52 publications with LMO2 and GATA1
 GATA2 antibody  >36 publications with LMO2 and GATA2
 LYL1 antibody  >20 publications with LMO2 and LYL1
 RLIM antibody  >2 publications with LMO2 and RLIM
 ELF2 antibody  >1 publications with LMO2 and ELF2
 BEX1 antibody  >1 publications with LMO2 and BEX1
 KDM5A antibody  >1 publications with LMO2 and KDM5A
 BEX2 antibody  >1 publications with LMO2 and BEX2

Pathways associated with anti-LMO2 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-LMO2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >175 publications with LMO2 and Neoplasms
 Leukemia, T-Cell Antibodies  >106 publications with LMO2 and Leukemia, T-Cell
 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >25 publications with LMO2 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >20 publications with LMO2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >11 publications with LMO2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >5 publications with LMO2 and Nervous System Diseases
 Kidney Diseases Antibodies  >4 publications with LMO2 and Kidney Diseases
 Inflammation Antibodies  >3 publications with LMO2 and Inflammation
 Prostatic Neoplasms Antibodies  >3 publications with LMO2 and Prostatic Neoplasms
 Liver Diseases Antibodies  >3 publications with LMO2 and Liver Diseases

Organs/Tissues associated with anti-LMO2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >162 publications with LMO2 and Blood
 Bone Antibodies  >50 publications with LMO2 and Bone
 Vascular Antibodies  >41 publications with LMO2 and Vascular
 Bone Marrow Antibodies  >37 publications with LMO2 and Bone Marrow
 Embryonic Tissue Antibodies  >25 publications with LMO2 and Embryonic Tissue
 Liver Antibodies  >19 publications with LMO2 and Liver
 Kidney Antibodies  >14 publications with LMO2 and Kidney
 Lymph Node Antibodies  >12 publications with LMO2 and Lymph Node
 Heart Antibodies  >11 publications with LMO2 and Heart
 Brain Antibodies  >9 publications with LMO2 and Brain
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