Rabbit Anti-IL22RA1 Polyclonal Antibody – Cat# MBS647943

Human Spleen (formalin-fixed, paraffin-embedded) stained antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

IL22RA1 Antibody – Rabbit Polyclonal

Name: IL22RA1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647943
Price: 915 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647943

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor… More details

$915 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL22R (IL22RA1), Polyclonal Antibody

Full Product Name

IL22R, NT (IL22RA1, Interleukin-22 Receptor Subunit alpha-1, IL-22 Receptor Subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine Receptor Class-II Member 9, Cytokine Receptor Family 2 Member 9, CRF2-9, ZcytoR11)

Product Gene Name

anti-IL22RA1 antibody

Product Synonym Names

Anti -IL22R, NT (IL22RA1, Interleukin-22 Receptor Subunit alpha-1, IL-22 Receptor Subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine Receptor Class-II Member 9, Cytokine Receptor Family 2 Member 9, CRF2-9, ZcytoR11)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human IL-22R. Species sequence homology: Rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

63,077 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (24446261..24469783, complement). Location: 1p36.11

OMIM

605457

3D Structure

ModBase 3D Structure for Q8N6P7

Immunogen

Synthetic peptide corresponding to aa from human IL-22R at N-terminal (KLH).

Product Categories/Family for anti-IL22RA1 antibody

Antibodies; Abs to Interleukin

Applications Tested/Suitable for anti-IL22RA1 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Application Notes for anti-IL22RA1 antibody

Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Other Notes

Small volumes of anti-IL22RA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22RA1 purchase

MBS647943 is an antibody targeting IL22RA1. Also known as IL22R, NT (IL22RA1, Interleukin-22 Receptor Subunit alpha-1, IL-22 Receptor Subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine Receptor Class-II Member 9, Cytokine Receptor Family 2 Member 9, CRF2-9, ZcytoR11). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22RA1. It may not necessarily be applicable to this product.

NCBI GI #

31317239

NCBI GeneID

58985

NCBI Accession #

NP_067081.2

UniProt Primary Accession #

Q8N6P7

UniProt Secondary Accession #

Q9HB22; A8K839; B2R9Y9

UniProt Related Accession #

Q8N6P7

GenBank Nucleotide #

NM_021258.3

NCBI Official Full Name

interleukin-22 receptor subunit alpha-1

NCBI Official Synonym Full Names

interleukin 22 receptor, alpha 1

NCBI Official Symbol

IL22RA1

NCBI Official Synonym Symbols

IL22R; CRF2-9; IL22R1

UniProt Protein Name

Interleukin-22 receptor subunit alpha-1

UniProt Synonym Protein Names

Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11

Protein Family

Interleukin-22 receptor

UniProt Gene Name

IL22RA1

UniProt Synonym Gene Names

IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9

UniProt Entry Name

I22R1_HUMAN

NCBI Protein Information

interleukin-22 receptor subunit alpha-1; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9

NCBI Summary for IL22RA1

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

UniProt Comments for IL22RA1

Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Ref.6 Ref.7 Ref.9 Ref.10 Ref.11 Ref.14

Subunit structure: Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone. Ref.6 Ref.13

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. Ref.8 Ref.12 Ref.15 Ref.17 Ref.18

Induction: By IFNG/IFN-gamma in keratinocytes. Ref.12

Miscellaneous: Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

Sequence similarities: Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.

Research Articles on IL22RA1

1. Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL22RA1 antibody

Reference Product	PubMed Publications
IL22 antibody	>3 publications with IL22RA1 and IL22
IL20 antibody	>1 publications with IL22RA1 and IL20
IL24 antibody	>1 publications with IL22RA1 and IL24
IL10RB antibody	>1 publications with IL22RA1 and IL10RB

Pathways associated with anti-IL22RA1 antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL22RA1 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>1 publications with IL22RA1 and Breast Neoplasms
Atherosclerosis Antibodies	>1 publications with IL22RA1 and Atherosclerosis
Neoplasms Antibodies	>1 publications with IL22RA1 and Neoplasms
Inflammation Antibodies	>1 publications with IL22RA1 and Inflammation

Organs/Tissues associated with anti-IL22RA1 antibody

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>1 publications with IL22RA1 and Thyroid
Skin Antibodies	>1 publications with IL22RA1 and Skin