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PRELP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647988

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRELP, Polyclonal Antibody
Full Product Name
PRELP, ID (PRELP, SLRR2A, Prolargin, Proline-arginine-rich end leucine-rich repeat protein)
Product Gene Name
anti-PRELP antibody
Product Synonym Names
Anti -PRELP, ID (PRELP, SLRR2A, Prolargin, Proline-arginine-rich end leucine-rich repeat protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,810 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (203444883..203460480). Location: 1q32
OMIM
601914
3D Structure
ModBase 3D Structure for P51888
Immunogen
PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-155 amino acids from the Central region of human PRELP.

Product Categories/Family for anti-PRELP antibody

Antibodies; Abs to Leucine-rich Proteins
Applications Tested/Suitable for anti-PRELP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PRELP antibody
Suitable for use in Western Blot, Immunohistochemistry
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-PRELP antibody

Western Blot analysis in mouse heart tissue lysates (15ug/lane)using MBS647988. This demonstrates that MBS647988 detected PRELP protein (arrow).
Rabbit Anti-PRELP Polyclonal Antibody – Cat# MBS647988

Immunohistochemistry (IHC) of anti-PRELP antibody

IHC analysis in formalin fixed and paraffin embedded breast carcinoma using MBS647988 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS647988 for immunohistochemistry.
Rabbit Anti-PRELP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647988

Other Notes

Small volumes of anti-PRELP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRELP purchase

MBS647988 is an antibody targeting PRELP. Also known as PRELP, ID (PRELP, SLRR2A, Prolargin, Proline-arginine-rich end leucine-rich repeat protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRELP. It may not necessarily be applicable to this product.

NCBI GI #
41349454
NCBI GeneID
5549
NCBI Accession #
NP_958505.1
UniProt Primary Accession #
P51888
UniProt Secondary Accession #
Q6FG38
UniProt Related Accession #
P51888
GenBank Nucleotide #
NM_201348.1
NCBI Official Full Name
prolargin
NCBI Official Synonym Full Names
proline/arginine-rich end leucine-rich repeat protein
NCBI Official Symbol
PRELP
NCBI Official Synonym Symbols
MST161; SLRR2A; MSTP161
UniProt Protein Name
Prolargin
UniProt Synonym Protein Names
Proline-arginine-rich end leucine-rich repeat protein
Protein Family
Prolargin
UniProt Gene Name
PRELP
UniProt Synonym Gene Names
SLRR2A
UniProt Entry Name
PRELP_HUMAN
NCBI Protein Information
prolargin; prolargin proteoglycan; proline-arginine-rich end leucine-rich repeat protein; 55 kDa leucine-rich repeat protein of articular cartilage

NCBI Summary for PRELP

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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UniProt Comments for PRELP

Function: May anchor basement membranes to the underlying connective tissue

By similarity.

Subunit structure: Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix.

Tissue specificity: Connective tissue.

Domain: The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain

By similarity.

Sequence similarities: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.Contains 12 LRR (leucine-rich) repeats.
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Research Articles on PRELP

1. PRELP may down-regulate complement attack at basement membranes and on damaged cartilage and therefore limit pathological complement activation in inflammatory disease such as RA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRELP antibody

 Reference Product  PubMed Publications
 FMOD antibody  >4 publications with PRELP and FMOD
 LUM antibody  >2 publications with PRELP and LUM
 KERA antibody  >1 publications with PRELP and KERA
 OGN antibody  >1 publications with PRELP and OGN

Pathways associated with anti-PRELP antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram

Diseases associated with anti-PRELP antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with PRELP and Nervous System Diseases
 Bone Diseases Antibodies  >3 publications with PRELP and Bone Diseases
 Arteriosclerosis Antibodies  >2 publications with PRELP and Arteriosclerosis
 Immune System Diseases Antibodies  >2 publications with PRELP and Immune System Diseases
 Neoplasms Antibodies  >2 publications with PRELP and Neoplasms
 Atherosclerosis Antibodies  >2 publications with PRELP and Atherosclerosis
 Hypertension Antibodies  >1 publications with PRELP and Hypertension
 Fibrosis Antibodies  >1 publications with PRELP and Fibrosis
 Necrosis Antibodies  >1 publications with PRELP and Necrosis
 Inflammation Antibodies  >1 publications with PRELP and Inflammation

Organs/Tissues associated with anti-PRELP antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with PRELP and Bone
 Connective Tissue Antibodies  >12 publications with PRELP and Connective Tissue
 Skin Antibodies  >5 publications with PRELP and Skin
 Brain Antibodies  >5 publications with PRELP and Brain
 Muscle Antibodies  >3 publications with PRELP and Muscle
 Kidney Antibodies  >3 publications with PRELP and Kidney
 Eye Antibodies  >3 publications with PRELP and Eye
 Lung Antibodies  >2 publications with PRELP and Lung
 Liver Antibodies  >2 publications with PRELP and Liver
 Adipose Tissue Antibodies  >2 publications with PRELP and Adipose Tissue
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