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SEC63 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647996

MBS647996 is an antibody targeting SEC63. Also known as SEC63 (Translocation Protein SEC63 Homolog, SEC63L, DNAJC23, ERdj2, PRO2507). Reactive in Human. Host: Mouse. More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SEC63, Polyclonal Antibody
Full Product Name
SEC63 (Translocation Protein SEC63 Homolog, SEC63L, DNAJC23, ERdj2, PRO2507)
Product Gene Name
anti-SEC63 antibody
Product Synonym Names
Anti -SEC63 (Translocation Protein SEC63 Homolog, SEC63L, DNAJC23, ERdj2, PRO2507)
Immunogen Sequence
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN HKKYKIKTIQ DLVSLKESDR HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPAEDG QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL LPQSKQQKQK QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE EEEEEEEDDD
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SEC63.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
87,997 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (108188960..108279482, complement). Location: 6q21
OMIM
174050
3D Structure
ModBase 3D Structure for Q9UGP8
Immunogen
Full length human SEC63, aa1-760 (NP_009145.1).

Product Categories/Family for anti-SEC63 antibody

Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-SEC63 antibody
Western Blot (WB)
Application Notes for anti-SEC63 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-SEC63 antibody

SEC63 polyclonal antibody. Western Blot analysis of SEC63 expression in human pancreas.
Mouse Anti-SEC63 Polyclonal Antibody – Cat# MBS647996

Western Blot (WB) of anti-SEC63 antibody

SEC63 polyclonal antibody. Western Blot analysis of SEC63 expression in A-431.
Mouse Anti-SEC63 Polyclonal Antibody, Western Blot (WB) – Cat# MBS647996

Western Blot (WB) of anti-SEC63 antibody

Western Blot analysis of SEC63 expression in transfected 293T cell line by SEC63 polyclonal antibody. Lane 1: SEC63 transfected lysate (83.6kD). Lane 2: Non-transfected lysate
Mouse Anti-SEC63 Polyclonal Antibody, Western Blot (WB) – Cat# MBS647996

Other Notes

Small volumes of anti-SEC63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SEC63. It may not necessarily be applicable to this product.

NCBI GI #
3978517
NCBI GeneID
11231
NCBI Accession #
AAC83375.1
UniProt Primary Accession #
Q9UGP8
UniProt Secondary Accession #
O95380; Q5THN4; Q86VS9; Q8IWL0; Q9NTE0
UniProt Related Accession #
Q9UGP8
NCBI Official Full Name
SEC63
NCBI Official Synonym Full Names
SEC63 homolog (S. cerevisiae)
NCBI Official Symbol
SEC63
NCBI Official Synonym Symbols
ERdj2; SEC63L; DNAJC23; PRO2507
UniProt Protein Name
Translocation protein SEC63 homolog
Protein Family
Protein translocation protein
UniProt Gene Name
SEC63
UniProt Synonym Gene Names
SEC63L
UniProt Entry Name
SEC63_HUMAN
NCBI Protein Information
translocation protein SEC63 homolog

NCBI Summary for SEC63

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
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UniProt Comments for SEC63

Function: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Subunit structure: Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity: Widely expressed, with high levels in the liver. Ref.6

Involvement in disease: Polycystic liver disease (PCLD) [MIM:174050]: A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities: Contains 1 J domain.Contains 2 SEC63 domains.

Sequence caution: The sequence AAH23598.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
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Research Articles on SEC63

1. a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEC63 antibody

 Reference Product  PubMed Publications
 SEC62 antibody  >32 publications with SEC63 and SEC62
 PRKCSH antibody  >19 publications with SEC63 and PRKCSH
 SEC61A1 antibody  >3 publications with SEC63 and SEC61A1

Pathways associated with anti-SEC63 antibody

 Products by Pathway  Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-SEC63 antibody

 Disease Name  Pubmed Publications
 Polycystic liver disease Antibodies  >22 publications with SEC63 and Polycystic liver disease
 Neoplasms Antibodies  >20 publications with SEC63 and Neoplasms
 Liver Diseases Antibodies  >18 publications with SEC63 and Liver Diseases
 Kidney Diseases Antibodies  >12 publications with SEC63 and Kidney Diseases
 Polycystic Kidney Diseases Antibodies  >12 publications with SEC63 and Polycystic Kidney Diseases
 Congenital Abnormalities Antibodies  >2 publications with SEC63 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with SEC63 and Nervous System Diseases
 Pain Antibodies  >1 publications with SEC63 and Pain
 Liver Neoplasms Antibodies  >1 publications with SEC63 and Liver Neoplasms
 Weight Loss Antibodies  >1 publications with SEC63 and Weight Loss

Organs/Tissues associated with anti-SEC63 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >24 publications with SEC63 and Liver
 Kidney Antibodies  >12 publications with SEC63 and Kidney
 Blood Antibodies  >3 publications with SEC63 and Blood
 Pancreas Antibodies  >3 publications with SEC63 and Pancreas
 Stomach Antibodies  >2 publications with SEC63 and Stomach
 Nerve Antibodies  >2 publications with SEC63 and Nerve
 Heart Antibodies  >2 publications with SEC63 and Heart
 Placenta Antibodies  >1 publications with SEC63 and Placenta
 Vascular Antibodies  >1 publications with SEC63 and Vascular
 Intestine Antibodies  >1 publications with SEC63 and Intestine
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