SWAP-70 (SWAP70) Antibody – Goat Polyclonal

Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion

By similarity. Ref.1 Ref.8

Subunit structure: The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70

By similarity.

Subcellular location: Cytoplasm. Cell membrane. Nucleus. Cell projection › lamellipodium. Note: In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia. Ref.1 Ref.8

Tissue specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (Ref.1). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (Ref.8). Ref.1 Ref.8

Domain: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.

Post-translational modification: Tyrosine-phosphorylated. Ref.1

Sequence similarities: Contains 1 PH domain.

Sequence caution: The sequence AAF28999.1 differs from that shown. Reason: Frameshift at positions 480 and 483. The sequence BAA31615.1 differs from that shown. Reason: Erroneous initiation.