Rabbit Anti-SYNJ2 Polyclonal Antibody – Cat# MBS648049

Western Blot analysis of SYNJ2 expression in transfected 293T cell line by SYNJ2 polyclonal antibody. Lane 1: SYNJ2 transfected lysate (92.2kD). Lane 2: Non-transfected lysate.

SYNJ2 Antibody – Rabbit Polyclonal

Name: SYNJ2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648049
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648049

MBS648049 is an antibody targeting SYNJ2. Also known as SYNJ2 (Synaptojanin-2, Synaptic Inositol 1,4,5-trisphosphate 5-phosphatase 2, INPP5H, KIAA0348). Reactive in Human. Host: Rabbit. More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SYNJ2, Polyclonal Antibody

Full Product Name

SYNJ2 (Synaptojanin-2, Synaptic Inositol 1,4,5-trisphosphate 5-phosphatase 2, INPP5H, KIAA0348)

Product Gene Name

anti-SYNJ2 antibody

Product Synonym Names

Anti -SYNJ2 (Synaptojanin-2, Synaptic Inositol 1,4,5-trisphosphate 5-phosphatase 2, INPP5H, KIAA0348)

Immunogen Sequence

MGGKAGNKGA VGIRFQFHST SFCFICSHLT AGQSQVKERN EDYKEITQKL CFPMGRNVFS HDYVFWCGDF NYRIDLTYEE VFYFVKRQDW KKLLEFDQLQ LQKSSGKIFK DFHEGAINFG PTYKYDVGSA AYDTSDKCRT PAWTDRVLWW RKKHPFDKTA GELNLLDSDL DVDTKVRHTW SPGALQYYGR AELQASDHRP VLAIVEVEVQ EVDVGARERV FQEVSSFQGP LDATVVVNLQ SPTLEEKNEF PEDLRTELMQ TLGSYGTIVL VRINQGQMLV TFADSHSALS VLDVDGMKVK GRAVKIRPKT KDWLKGLREE IIRKRDSMAP VSPTANSCLL EENFDFTSLD YESEGDILED DEDYLVDEFN QPGVSDSELG GDDLSDVPGP TALAPPSKSP ALTKKKQHPT YKDDADLVEL KRELEAVGEF RHRSPSRSLS VPNRPRPPQP PQRPPPPTGL MVKKSASDAS ISSGTHGQYS ILQTARLLPG APQQPPKART GISKPYNVKQ IKTTNAQEAE AAIRCLLEAR GGASEEALSA VAPRDLEASS EPEPTPGAAK PETPQAPPLL PRRPPPRVPA IKKPTLRRTG KPLSPEEQFE QQTVHFTIGP PETSVEAPPV VTAPRVPPVP KPRTFQPGKA AERPSHRKPA SDEAPPGAGA SVPPPLEAPP LVPKVPPRRK KSAPAAFHLQ VLQSNSQLLQ GLTYNSSDSP SGHPPAAGTV FPQGDFLSTS SATSPDSDGT KAMKPEAAPL LGDYQDPFWN LLHHPKLLNN TWLSKSSDPL DSGTRSPKRD PIDPVSAGAS AAKAELPPDH GHKTLGHWVT ISDQEKRTAL QVFDPLAKT

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human SYNJ2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

165,538 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (158402888..158520208). Location: 6q25.3

OMIM

609410

3D Structure

ModBase 3D Structure for O15056

Immunogen

Full length human SYNJ2, aa1-839 (AAH43277.1).

Product Categories/Family for anti-SYNJ2 antibody

Antibodies; Abs to Enzymes; Phosphatase

Applications Tested/Suitable for anti-SYNJ2 antibody

Western Blot (WB)

Application Notes for anti-SYNJ2 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-SYNJ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SYNJ2. It may not necessarily be applicable to this product.

NCBI GI #

296010889

NCBI GeneID

8871

NCBI Accession #

NP_001171559.1

UniProt Primary Accession #

O15056

UniProt Secondary Accession #

Q5TA13; Q5TA16; Q5TA19; Q86XK0; Q8IZA8; Q9H226

UniProt Related Accession #

O15056

GenBank Nucleotide #

NM_001178088.1

NCBI Official Full Name

synaptojanin-2 isoform 2

NCBI Official Synonym Full Names

synaptojanin 2

NCBI Official Symbol

SYNJ2

NCBI Official Synonym Symbols

INPP5H

UniProt Protein Name

Synaptojanin-2

UniProt Synonym Protein Names

Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2

Protein Family

Synaptojanin

UniProt Gene Name

SYNJ2

UniProt Synonym Gene Names

KIAA0348

UniProt Entry Name

SYNJ2_HUMAN

NCBI Protein Information

synaptojanin-2; inositol phosphate 5'-phosphatase 2; synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2

NCBI Summary for SYNJ2

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

UniProt Comments for SYNJ2

Function: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

Subunit structure: Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

Subcellular location: Membrane

By similarity. Note: Predominantly associated with the particulate fractions

By similarity. Ref.2

Sequence similarities: Belongs to the synaptojanin family.In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Contains 1 RRM (RNA recognition motif) domain.Contains 1 SAC domain.

Sequence caution: The sequence AAH43277.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on SYNJ2

1. Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SYNJ2 antibody

Products by Pathway	Pathway Diagram
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies	1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies	1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
3-phosphoinositide Degradation Pathway antibodies	3-phosphoinositide Degradation Pathway Diagram
3-phosphoinositide Degradation Pathway antibodies	3-phosphoinositide Degradation Pathway Diagram
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies	D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies	D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram

Diseases associated with anti-SYNJ2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with SYNJ2 and Nervous System Diseases
Neoplasms Antibodies	>2 publications with SYNJ2 and Neoplasms
Prostatic Neoplasms Antibodies	>1 publications with SYNJ2 and Prostatic Neoplasms
Prostatic Diseases Antibodies	>1 publications with SYNJ2 and Prostatic Diseases

Organs/Tissues associated with anti-SYNJ2 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>4 publications with SYNJ2 and Nerve
Brain Antibodies	>4 publications with SYNJ2 and Brain
Ganglia Antibodies	>1 publications with SYNJ2 and Ganglia
Prostate Antibodies	>1 publications with SYNJ2 and Prostate
Ear Antibodies	>1 publications with SYNJ2 and Ear