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SSR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648051

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SSR2, Polyclonal Antibody
Full Product Name
SSR2, CT (SSR2, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta)
Product Gene Name
Product Synonym Names
Anti -SSR2, CT (SSR2, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
20,135 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (155978839..155990758, complement). Location: 1q21-q23
OMIM
600867
3D Structure
ModBase 3D Structure for P43308
Immunogen
SSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-183 amino acids from the C-terminal region of human SSR2.

Product Categories/Family for anti-SSR2 antibody

Applications Tested/Suitable for anti-SSR2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-SSR2 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-SSR2 antibody

Western Blot analysis in human placenta tissue and Jurkat, Hela, ZR-75-1 cell line lysates (35ug/lane) using MBS648051. This demonstrates that MBS648051 detected the SSR2 protein (arrow).
Rabbit Anti-SSR2 Polyclonal Antibody – Cat# MBS648051

Immunohistochemistry (IHC) of anti-SSR2 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue using MBS648051 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS648051 for immunohistochemistry.
Rabbit Anti-SSR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648051

Flow Cytometry (FC/FACS) of anti-SSR2 antibody

Flow Cytometric analysis of Jurkat cells using MBS648051 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SSR2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS648051

Other Notes

Small volumes of anti-SSR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SSR2 purchase

MBS648051 is an antibody targeting SSR2. Also known as SSR2, CT (SSR2, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SSR2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
SSR2
NCBI Official Synonym Full Names
signal sequence receptor, beta (translocon-associated protein beta)
NCBI Official Symbol
SSR2
NCBI Official Synonym Symbols
TLAP; HSD25; TRAPB; TRAP-BETA
UniProt Protein Name
Translocon-associated protein subunit beta
UniProt Synonym Protein Names
Signal sequence receptor subunit beta
UniProt Gene Name
SSR2
UniProt Synonym Gene Names
TRAPB; TRAP-beta; SSR-beta
UniProt Entry Name
SSRB_HUMAN
NCBI Protein Information
translocon-associated protein subunit beta; SSR-beta; translocon-associated protein beta; signal sequence receptor subunit beta

NCBI Summary for SSR2

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]
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UniProt Comments for SSR2

Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Subunit structure: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING. Ref.11

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the TRAP-beta family.

Sequence caution: The sequence CAH72631.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH72632.1 differs from that shown. Reason: Erroneous gene model prediction.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SSR2 antibody

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