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CUEDC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648107

CUEDC2 is a 287aa protein belonging to the CUEDC2 family with a CUE domain. CUEDC2 is known to interact with PGR and ESR1 with the help of its CUE domain. The exact function of CUEDC2 is yet unknown, but reports suggest that it interacts with PR and promotes… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CUEDC2, Polyclonal Antibody
Full Product Name
CUEDC2, CT (CUE Domain-containing Protein 2, C10orf66, HOYS6)
Product Gene Name
anti-CUEDC2 antibody
Product Synonym Names
Anti -CUEDC2, CT (CUE Domain-containing Protein 2, C10orf66, HOYS6)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CUEDC2. Species sequence homology: Mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
32,009 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (104183002..104192423, complement). Location: 10q24.32
OMIM
614142
3D Structure
ModBase 3D Structure for Q9H467
Immunogen
Synthetic peptide corresponding to 19aa from near the C-terminus of human CUEDC2.

Product Categories/Family for anti-CUEDC2 antibody

Antibodies; Abs to Nuclear Proteins
Applications Tested/Suitable for anti-CUEDC2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-CUEDC2 antibody
Suitable for use in ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-CUEDC2 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CUEDC2 Polyclonal Antibody – Cat# MBS648107

Immunohistochemistry (IHC) of anti-CUEDC2 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CUEDC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648107

Western Blot (WB) of anti-CUEDC2 antibody

Western blot analysis of CUEDC2 in HeLa cell lysate with CUEDC2 antibody at (A) 1 and (B) 2ug/ml
Rabbit Anti-CUEDC2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS648107

Immunocytochemistry (ICC) of anti-CUEDC2 antibody

Immunocytochemistry in HeLa cells with CUEDC2 antibody at 5ug/ml.
Rabbit Anti-CUEDC2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS648107

Other Notes

Small volumes of anti-CUEDC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CUEDC2 purchase

MBS648107 is an antibody targeting CUEDC2. Also known as CUEDC2, CT (CUE Domain-containing Protein 2, C10orf66, HOYS6). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CUEDC2. It may not necessarily be applicable to this product.

NCBI GI #
148596996
NCBI GeneID
79004
NCBI Accession #
NP_076945.2
UniProt Primary Accession #
Q9H467
UniProt Secondary Accession #
Q9BWG8; D3DR88
UniProt Related Accession #
Q9H467
GenBank Nucleotide #
NM_024040.2
NCBI Official Full Name
CUE domain-containing protein 2
NCBI Official Synonym Full Names
CUE domain containing 2
NCBI Official Symbol
CUEDC2
NCBI Official Synonym Symbols
C10orf66; bA18I14.5
UniProt Protein Name
CUE domain-containing protein 2
Protein Family
CUE domain-containing protein
UniProt Gene Name
CUEDC2
UniProt Synonym Gene Names
C10orf66
UniProt Entry Name
CUED2_HUMAN
NCBI Protein Information
CUE domain-containing protein 2

UniProt Comments for CUEDC2

Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Ref.6 Ref.9

Subunit structure: Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol. Ref.6 Ref.9

Subcellular location: Cytoplasm. Nucleus Ref.6.

Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Domain: The CUE domain mediates interaction with PGR and ESR1.

Involvement in disease: May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Sequence similarities: Belongs to the CUEDC2 family.Contains 1 CUE domain.

Sequence caution: The sequence AAH00262.1 differs from that shown. Reason: Erroneous termination at position 227. Translated as Glu.
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Research Articles on CUEDC2

1. In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC/C(Cdh1)-mediated cyclin A destruction, cyclin-dependent kinase 2 inactivation, and G1 arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CUEDC2 antibody

 Reference Product  PubMed Publications
 IKBKB antibody  >4 publications with CUEDC2 and IKBKB
 CDK1 antibody  >2 publications with CUEDC2 and CDK1
 CHUK antibody  >1 publications with CUEDC2 and CHUK
 MAD2L1 antibody  >1 publications with CUEDC2 and MAD2L1
 PPP1R15A antibody  >1 publications with CUEDC2 and PPP1R15A
 SOCS3 antibody  >1 publications with CUEDC2 and SOCS3

Diseases associated with anti-CUEDC2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with CUEDC2 and Neoplasms
 Breast Neoplasms Antibodies  >5 publications with CUEDC2 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CUEDC2 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >2 publications with CUEDC2 and Inflammation
 Necrosis Antibodies  >2 publications with CUEDC2 and Necrosis
 Prostatic Diseases Antibodies  >1 publications with CUEDC2 and Prostatic Diseases

Organs/Tissues associated with anti-CUEDC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with CUEDC2 and Blood
 Prostate Antibodies  >1 publications with CUEDC2 and Prostate
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