Mouse Anti-HLA-G Monoclonal Antibody – Cat# MBS648123

Human beta-2 microglobulin detected with M3890-02L, Mouse anti Human Beta-2 Microglobulin:HRP

B2-Microglobulin (HLA-G) Antibody – Mouse Monoclonal

Name: HLA-G Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648123
Price: 690 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648123

MBS648123 is an antibody targeting HLA-G. Also known as b2-Microglobulin (Beta-2-microglobulin, B2M, CDABP0092, HDCMA22P) (HRP). Reactive in Human. Host: Mouse. More details

$690 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

b2-Microglobulin (HLA-G), Monoclonal Antibody

Full Product Name

b2-Microglobulin (Beta-2-microglobulin, B2M, CDABP0092, HDCMA22P) (HRP)

Product Gene Name

anti-HLA-G antibody

Product Synonym Names

Anti -b2-Microglobulin (Beta-2-microglobulin, B2M, CDABP0092, HDCMA22P) (HRP)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

B2M-01

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.4, 0.1% thermisol. Labeled with HRP.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromarography.

Specificity

Recognizes human beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. Does not react with mouse, canine, rabbit, chicken or bovine.

Preparation and Storage

-20 degree C

Molecular Weight

38,224 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3

OMIM

142871

3D Structure

ModBase 3D Structure for P17693

Immunogen

Purified isolated human B2-microglobulin

Product Categories/Family for anti-HLA-G antibody

Antibodies; Abs to Serum Proteins

Applications Tested/Suitable for anti-HLA-G antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-HLA-G antibody

Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:250-1:2500

Storage and Stability:
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.

Other Notes

Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.

NCBI GI #

188468

NCBI GeneID

3135

NCBI Accession #

AAA59836.1

UniProt Primary Accession #

P17693

UniProt Related Accession #

P17693

NCBI Official Full Name

b2 microglobulin

NCBI Official Synonym Full Names

major histocompatibility complex, class I, G

NCBI Official Symbol

HLA-G

NCBI Official Synonym Symbols

MHC-G

UniProt Protein Name

HLA class I histocompatibility antigen, alpha chain G

UniProt Synonym Protein Names

HLA G antigen; MHC class I antigen G

Protein Family

HLA class I histocompatibility antigen

UniProt Gene Name

HLA-G

UniProt Synonym Gene Names

HLA-6.0; HLAG

UniProt Entry Name

HLAG_HUMAN

NCBI Protein Information

HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G

NCBI Summary for HLA-G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

UniProt Comments for HLA-G

Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Subunit structure: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2. Ref.6 Ref.8

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in trophoblasts.

Sequence similarities: Belongs to the MHC class I family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Research Articles on HLA-G

1. This meta-analysis suggests that the 14 bp insertion/deletion HLA-G allele is associated with increased risk of unexplained recurrent spontaneous abortion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-G antibody

Reference Product	PubMed Publications
CD4 antibody	>89 publications with HLA-G and CD4
IL10 antibody	>75 publications with HLA-G and IL10
LILRB2 antibody	>40 publications with HLA-G and LILRB2
KLRC1 antibody	>11 publications with HLA-G and KLRC1
LIF antibody	>11 publications with HLA-G and LIF
ADM2 antibody	>2 publications with HLA-G and ADM2
SPRY2 antibody	>1 publications with HLA-G and SPRY2

Pathways associated with anti-HLA-G antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-HLA-G antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>325 publications with HLA-G and Neoplasms
Adenocarcinoma Antibodies	>84 publications with HLA-G and Adenocarcinoma
Skin Diseases Antibodies	>63 publications with HLA-G and Skin Diseases
Inflammation Antibodies	>61 publications with HLA-G and Inflammation
Necrosis Antibodies	>43 publications with HLA-G and Necrosis
Nervous System Diseases Antibodies	>34 publications with HLA-G and Nervous System Diseases
Gastrointestinal Diseases Antibodies	>31 publications with HLA-G and Gastrointestinal Diseases
Asthma Antibodies	>27 publications with HLA-G and Asthma
Breast Neoplasms Antibodies	>24 publications with HLA-G and Breast Neoplasms
Cardiovascular Diseases Antibodies	>24 publications with HLA-G and Cardiovascular Diseases

Organs/Tissues associated with anti-HLA-G antibody

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>442 publications with HLA-G and Placenta
Lung Antibodies	>33 publications with HLA-G and Lung
Brain Antibodies	>27 publications with HLA-G and Brain
Thymus Antibodies	>22 publications with HLA-G and Thymus
Stomach Antibodies	>8 publications with HLA-G and Stomach
Intestine Antibodies	>7 publications with HLA-G and Intestine
Testis Antibodies	>5 publications with HLA-G and Testis
Pancreas Antibodies	>3 publications with HLA-G and Pancreas