• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SPECC1L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648173

MBS648173 is an antibody targeting SPECC1L. Also known as CYTSA, NT (SPECC1L, CYTSA, KIAA0376, Cytospin-A, Renal carcinoma antigen NY-REN-22, Sperm antigen with calponin homology and coiled-coil domains 1-like). Reactive in Mouse. Host: Rabbit. CYTSA is… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYTSA (SPECC1L), Polyclonal Antibody
Full Product Name
CYTSA, NT (SPECC1L, CYTSA, KIAA0376, Cytospin-A, Renal carcinoma antigen NY-REN-22, Sperm antigen with calponin homology and coiled-coil domains 1-like)
Product Gene Name
anti-SPECC1L antibody
Product Synonym Names
Anti -CYTSA, NT (SPECC1L, CYTSA, KIAA0376, Cytospin-A, Renal carcinoma antigen NY-REN-22, Sperm antigen with calponin homology and coiled-coil domains 1-like)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
124,602 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (24666785..24813708). Location: 22q11.23
OMIM
600251
3D Structure
ModBase 3D Structure for Q69YQ0
Immunogen
CYTSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human CYTSA.

Product Categories/Family for anti-SPECC1L antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-SPECC1L antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SPECC1L antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-SPECC1L antibody

CYTSA Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CYTSA antibody detected the CYTSA protein (arrow).
Rabbit Anti-SPECC1L Polyclonal Antibody – Cat# MBS648173

Immunohistochemistry (IHC) of anti-SPECC1L antibody

CYTSA Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYTSA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SPECC1L Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648173

Other Notes

Small volumes of anti-SPECC1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPECC1L. It may not necessarily be applicable to this product.

NCBI GI #
513788264
NCBI GeneID
23384
NCBI Accession #
NP_001241661.2
UniProt Primary Accession #
Q69YQ0
UniProt Secondary Accession #
O15081; B7Z758; F5H1H6
UniProt Related Accession #
Q69YQ0
GenBank Nucleotide #
NM_001254732.2
NCBI Official Full Name
cytospin-A isoform 2
NCBI Official Synonym Full Names
sperm antigen with calponin homology and coiled-coil domains 1-like
NCBI Official Symbol
SPECC1L
NCBI Official Synonym Symbols
CYTSA; OBLFC1
UniProt Protein Name
Cytospin-A
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-22; Sperm antigen with calponin homology and coiled-coil domains 1-like
Protein Family
Cytospin
UniProt Gene Name
SPECC1L
UniProt Synonym Gene Names
CYTSA; KIAA0376; SPECC1-like protein
UniProt Entry Name
CYTSA_HUMAN
NCBI Protein Information
cytospin-A; SPECC1-like protein; renal carcinoma antigen NY-REN-22; cytokinesis and spindle organization A

NCBI Summary for SPECC1L

This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Show more

UniProt Comments for SPECC1L

Function: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. Ref.10

Subunit structure: May interact with both microtubules and actin cytoskeleton.

Subcellular location: Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › spindle. Cell junction › gap junction. Note: Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center. Ref.10

Involvement in disease: Facial clefting, oblique, 1 (OBLFC1) [MIM:600251]: A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Sequence similarities: Belongs to the cytospin-A family.Contains 1 CH (calponin-homology) domain.
Show more

Research Articles on SPECC1L

1. The authors use rapid amplification of cDNA ends, tiling arrays, and deep RNA sequencing to identify chimeric transcripts on human chromosomes 21 and 22. They found that for 492 protein coding genes studied, 85% of these genes had boundaries that extended beyond the current annotated termini.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-SPECC1L antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with SPECC1L and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000