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AVIL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648218

AVIL is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AVIL, Polyclonal Antibody
Full Product Name
AVIL, NT (AVIL, Advillin, p92)
Product Gene Name
anti-AVIL antibody
Product Synonym Names
Anti -AVIL, NT (AVIL, Advillin, p92)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
92,027 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (58190415..58210193, complement). Location: 12q14.1
OMIM
613397
3D Structure
ModBase 3D Structure for O75366
Immunogen
AVIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~212 amino acids from the N-terminal region of human AVIL.

Product Categories/Family for anti-AVIL antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-AVIL antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-AVIL antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-AVIL antibody

Western blot analysis of AVIL Antibody (N-term) in K562 cell line lysates (35ug/lane). AVIL (arrow) was detected using the purified Pab.
Rabbit Anti-AVIL Polyclonal Antibody – Cat# MBS648218

Immunohistochemistry (IHC) of anti-AVIL antibody

AVIL Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AVIL Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-AVIL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648218

Flow Cytometry (FC/FACS) of anti-AVIL antibody

AVIL Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-AVIL Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS648218

Other Notes

Small volumes of anti-AVIL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AVIL purchase

MBS648218 is an antibody targeting AVIL. Also known as AVIL, NT (AVIL, Advillin, p92). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AVIL. It may not necessarily be applicable to this product.

NCBI GI #
295821173
NCBI GeneID
10677
NCBI Accession #
NP_006567.3
UniProt Primary Accession #
O75366
UniProt Secondary Accession #
Q2NKM9; B2RAU7
UniProt Related Accession #
O75366
GenBank Nucleotide #
NM_006576.3
NCBI Official Full Name
advillin
NCBI Official Synonym Full Names
advillin
NCBI Official Symbol
AVIL
NCBI Official Synonym Symbols
p92; DOC6; ADVIL
UniProt Protein Name
Advillin
UniProt Synonym Protein Names
p92
Protein Family
Advillin
UniProt Gene Name
AVIL
UniProt Entry Name
AVIL_HUMAN
NCBI Protein Information
advillin

NCBI Summary for AVIL

The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]

UniProt Comments for AVIL

Function: Ca2+-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Ref.7

Subunit structure: Associates (via C-terminus) with actin. Interacts with SCARF1

By similarity. Interacts with F-actin. Ref.8

Subcellular location: Cytoplasm › cytoskeleton. Cell projection

By similarity. Cell projection › axon

By similarity.

Tissue specificity: Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. Ref.6

Sequence similarities: Belongs to the villin/gelsolin family.Contains 6 gelsolin-like repeats.Contains 1 HP (headpiece) domain.
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Research Articles on AVIL

1. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AVIL antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >178 publications with AVIL and Nervous System Diseases
 Poisoning Antibodies  >133 publications with AVIL and Poisoning
 Cardiovascular Diseases Antibodies  >103 publications with AVIL and Cardiovascular Diseases
 Neoplasms Antibodies  >60 publications with AVIL and Neoplasms
 Inflammation Antibodies  >50 publications with AVIL and Inflammation
 Heart Diseases Antibodies  >43 publications with AVIL and Heart Diseases
 Disease Models, Animal Antibodies  >43 publications with AVIL and Disease Models, Animal
 Liver Diseases Antibodies  >27 publications with AVIL and Liver Diseases
 Anxiety Disorders Antibodies  >19 publications with AVIL and Anxiety Disorders
 Carcinoma Antibodies  >15 publications with AVIL and Carcinoma

Organs/Tissues associated with anti-AVIL antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >325 publications with AVIL and Brain
 Muscle Antibodies  >155 publications with AVIL and Muscle
 Heart Antibodies  >123 publications with AVIL and Heart
 Lung Antibodies  >110 publications with AVIL and Lung
 Intestine Antibodies  >71 publications with AVIL and Intestine
 Nerve Antibodies  >62 publications with AVIL and Nerve
 Mouth Antibodies  >39 publications with AVIL and Mouth
 Kidney Antibodies  >27 publications with AVIL and Kidney
 Bone Antibodies  >14 publications with AVIL and Bone
 Ganglia Antibodies  >12 publications with AVIL and Ganglia
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