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LARP6 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648231

LARP6 is a member of the La ribonucleoprotein domain family, which all contain one characteristic La motif. LARP6 shuttles between the cytoplasm and nucleus. It is proposed that members of this family play a role in translation and mRNA stability. More details

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Product Overview

Online Datasheet in PDF
Product Name
LARP6, Polyclonal Antibody
Full Product Name
LARP6 (La-related Protein 6, Acheron, La Ribonucleoprotein Domain Family Member 6, FLJ11196)
Product Gene Name
Product Synonym Names
Anti -LARP6 (La-related Protein 6, Acheron, La Ribonucleoprotein Domain Family Member 6, FLJ11196)
Immunogen Sequence
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human LARP6.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
54,737 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (71123889..71146498, complement). Location: 15q23
OMIM
611300
3D Structure
ModBase 3D Structure for Q9BRS8
Immunogen
Full length human LARP6, aa1-491 (NP_060827).
Applications Tested/Suitable for anti-LARP6 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-LARP6 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-LARP6 antibody

Western Blot analysis of LARP6 expression in transfected 293T cell line by LARP6 polyclonal antibody. Lane 1: LARP6 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.
Mouse Anti-LARP6 Polyclonal Antibody – Cat# MBS648231

Immunofluorescence (IF) of anti-LARP6 antibody

Immunofluorescence of purified antibody to LARP6 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-LARP6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS648231

Other Notes

Small volumes of anti-LARP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LARP6 purchase

MBS648231 is an antibody targeting LARP6. Also known as LARP6 (La-related Protein 6, Acheron, La Ribonucleoprotein Domain Family Member 6, FLJ11196). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LARP6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
la-related protein 6 isoform 2
NCBI Official Synonym Full Names
La ribonucleoprotein domain family, member 6
NCBI Official Symbol
LARP6
NCBI Official Synonym Symbols
ACHN
UniProt Protein Name
La-related protein 6
UniProt Synonym Protein Names
Acheron; Achn; La ribonucleoprotein domain family member 6
Protein Family
UniProt Gene Name
LARP6
UniProt Synonym Gene Names
Achn
UniProt Entry Name
LARP6_HUMAN
NCBI Protein Information
la-related protein 6; acheron; death-associated LA motif protein

UniProt Comments for LARP6

Function: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. Ref.7 Ref.8 Ref.9

Subunit structure: Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9. Ref.7 Ref.8 Ref.9

Subcellular location: Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.1

Tissue specificity: Expressed in numerous tissues. Ref.1

Domain: The RRM domain mediates the association with collagen mRNAs stem-loops.

Sequence similarities: Contains 1 HTH La-type RNA-binding domain.Contains 1 RRM (RNA recognition motif) domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-LARP6 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with LARP6 and Inflammation

Organs/Tissues associated with anti-LARP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with LARP6 and Liver
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