Rabbit Anti-CELF4 Polyclonal Antibody – Cat# MBS648238

Western Blot analysis of BRUNOL4 expression in transfected 293T cell line by BRUNOL4 polyclonal antibody. Lane 1: BRUNOL4 transfected lysate (51.8kD). Lane 2: Non-transfected lysate.

CELF4 Antibody – Rabbit Polyclonal

Name: CELF4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648238
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648238

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CELF4, Polyclonal Antibody

Full Product Name

CELF4 (BRUNOL4, CUGBP Elav-like Family Member 4, CELF-4, Bruno-like Protein 4, CUG-BP- and ETR-3-like Factor 4, RNA-binding Protein BRUNOL-4)

Product Gene Name

anti-CELF4 antibody

Product Synonym Names

Anti -CELF4 (BRUNOL4, CUGBP Elav-like Family Member 4, CELF-4, Bruno-like Protein 4, CUG-BP- and ETR-3-like Factor 4, RNA-binding Protein BRUNOL-4)

Immunogen Sequence

MYIKMATLAN GQADNASLST NGLGSSPGSA GHMNGLSHSP GNPSTIPMKD HDAIKLFIGQ IPRNLDEKDL KPLFEEFGKI YELTVLKDRF TGMHKGCAFL TYCERESALK AQSALHEQKT LPGMNRPIQV KPADSESRGG SSCLRQPPSH RKLFVGMLNK QQSEDDVRRL FEAFGNIEEC TILRGPDGNS KGCAFVKYSS HAEAQAAINA LHGSQTMPGA SSSLVVKFAD TDKERTMRRM QQMAGQMGMF NPMAIPFGAY GAYAQALMQQ QAALMASVAQ GGYLNPMAAF AAAQMQQMAA LNMNGLAAAP MTPTSGGSTP PGITAPAVPS IPSPIGVNGF TGLPPQANGQ PAAEAVFANG IHPYPAQSPT AADPLQQAYA GVQQYAAAAY PAAYGQISQA FPQPPPMIPQ QQREGPEGCN LFIYHLPQEF GDAELMQMFL PFGFVSFDNP ASAQTAIQAM NGFQIGMKRL KVQLKRPKDA NRPY

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human BRUNOL4.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

51,966 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (34823003..35146000, complement). Location: 18q12

OMIM

612679

3D Structure

ModBase 3D Structure for Q9BZC1

Immunogen

Full length human BRUNOL4, aa1-484 (AAH01946.2).

Product Categories/Family for anti-CELF4 antibody

Antibodies; Abs to RNA Binding Proteins

Applications Tested/Suitable for anti-CELF4 antibody

Western Blot (WB)

Application Notes for anti-CELF4 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-CELF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CELF4 purchase

MBS648238 is an antibody targeting CELF4. Also known as CELF4 (BRUNOL4, CUGBP Elav-like Family Member 4, CELF-4, Bruno-like Protein 4, CUG-BP- and ETR-3-like Factor 4, RNA-binding Protein BRUNOL-4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CELF4. It may not necessarily be applicable to this product.

NCBI GI #

187761303

NCBI GeneID

56853

NCBI Accession #

NP_001020260.1

UniProt Primary Accession #

Q9BZC1

UniProt Secondary Accession #

Q59EN7; Q86XB9; Q8N2M6; Q9BQ96; Q9NR84; Q9NR85

UniProt Related Accession #

Q9BZC1

GenBank Nucleotide #

NM_001025089.1

NCBI Official Full Name

CUGBP Elav-like family member 4 isoform 4

NCBI Official Synonym Full Names

CUGBP, Elav-like family member 4

NCBI Official Symbol

CELF4

NCBI Official Synonym Symbols

BRUNOL4; BRUNOL-4

UniProt Protein Name

CUGBP Elav-like family member 4

UniProt Synonym Protein Names

Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4

Protein Family

CUGBP Elav-like family

UniProt Gene Name

CELF4

UniProt Synonym Gene Names

BRUNOL4; CELF-4

UniProt Entry Name

CELF4_HUMAN

NCBI Protein Information

CUGBP Elav-like family member 4; CELF-4; bruno-like protein 4; RNA-binding protein BRUNOL4; RNA-binding protein BRUNOL-4; LYST-interacting protein LIP9; CUG-BP and ETR-3 like factor 4; CUG-BP- and ETR-3-like factor 4; bruno-like 4, RNA binding protein; Bruno -like 4, RNA binding protein

NCBI Summary for CELF4

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CELF4

Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10

Subcellular location: Nucleus. Cytoplasm Ref.9.

Tissue specificity: Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes. Ref.1 Ref.6 Ref.11

Sequence similarities: Belongs to the CELF/BRUNOL family.Contains 3 RRM (RNA recognition motif) domains.

Sequence caution: The sequence BAD93011.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on CELF4

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CELF4 antibody

Products by Pathway	Pathway Diagram
MRNA Processing Pathway antibodies	MRNA Processing Pathway Diagram

Diseases associated with anti-CELF4 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>6 publications with CELF4 and Brain Diseases
Disease Models, Animal Antibodies	>2 publications with CELF4 and Disease Models, Animal
Hypertrophy Antibodies	>1 publications with CELF4 and Hypertrophy
Neurobehavioral Manifestations Antibodies	>1 publications with CELF4 and Neurobehavioral Manifestations
Heart Defects, Congenital Antibodies	>1 publications with CELF4 and Heart Defects, Congenital
Congenital Abnormalities Antibodies	>1 publications with CELF4 and Congenital Abnormalities
Neoplasms Antibodies	>1 publications with CELF4 and Neoplasms