• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MCHR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648282

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MCHR1, Polyclonal Antibody
Full Product Name
MCHR1, CT (MCHR1, GPR24, SLC1, Melanin-concentrating hormone receptor 1, G-protein coupled receptor 24, MCH-1R, SLC-1, Somatostatin receptor-like protein)
Product Gene Name
anti-MCHR1 antibody
Product Synonym Names
Anti -MCHR1, CT (MCHR1, GPR24, SLC1, Melanin-concentrating hormone receptor 1, G-protein coupled receptor 24, MCH-1R, SLC-1, Somatostatin receptor-like protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,963 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (41075182..41078818). Location: 22q13.2
OMIM
601751
3D Structure
ModBase 3D Structure for Q99705
Immunogen
MCHR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-426 amino acids from the C-terminal region of human MCHR1.

Product Categories/Family for anti-MCHR1 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-MCHR1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-MCHR1 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Immunohistochemistry (IHC) of anti-MCHR1 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue with MBS648282 which was peroxidase conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of 038275 for immunohistochemistry.
Rabbit Anti-MCHR1 Polyclonal Antibody – Cat# MBS648282

Flow Cytometry (FC/FACS) of anti-MCHR1 antibody

Flow cytometric analysis of K562 cells using MBS648282 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-MCHR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS648282

Western Blot (WB) of anti-MCHR1 antibody

Western Blot analysis in CEM,K562 cell line lysates (35ug/lane) using 038275. This demonstrates that MBS648282 detected the MCHR1 protein (arrow).
Rabbit Anti-MCHR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS648282

Other Notes

Small volumes of anti-MCHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCHR1 purchase

MBS648282 is an antibody targeting MCHR1. Also known as MCHR1, CT (MCHR1, GPR24, SLC1, Melanin-concentrating hormone receptor 1, G-protein coupled receptor 24, MCH-1R, SLC-1, Somatostatin receptor-like protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCHR1. It may not necessarily be applicable to this product.

NCBI GI #
88758590
NCBI GeneID
2847
NCBI Accession #
NP_005288.3
UniProt Primary Accession #
Q99705
UniProt Secondary Accession #
Q5R3J1; Q96S47; Q9BV08; B2RBX6
UniProt Related Accession #
Q99705
GenBank Nucleotide #
NM_005297.3
NCBI Official Full Name
melanin-concentrating hormone receptor 1
NCBI Official Synonym Full Names
melanin-concentrating hormone receptor 1
NCBI Official Symbol
MCHR1
NCBI Official Synonym Symbols
SLC1; GPR24; MCH1R; SLC-1; MCH-1R
UniProt Protein Name
Melanin-concentrating hormone receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein
Protein Family
Melanin-concentrating hormone receptor
UniProt Gene Name
MCHR1
UniProt Synonym Gene Names
GPR24; SLC1; MCH receptor 1; MCH-R1; MCHR-1; MCH1R; MCHR
UniProt Entry Name
MCHR1_HUMAN
NCBI Protein Information
melanin-concentrating hormone receptor 1; MCH receptor 1; G protein-coupled receptor 24; somatostatin receptor-like protein

UniProt Comments for MCHR1

Function: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Ref.11

Subunit structure: Interacts with NCDN. Ref.12

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Caution: It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.

Sequence caution: The sequence AAC14587.1 differs from that shown. Reason: Erroneous gene model prediction.
Show more

Research Articles on MCHR1

1. results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCHR1 antibody

 Reference Product  PubMed Publications
 POMC antibody  >6 publications with MCHR1 and POMC
 SST antibody  >2 publications with MCHR1 and SST
 NPY antibody  >2 publications with MCHR1 and NPY

Pathways associated with anti-MCHR1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-MCHR1 antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >21 publications with MCHR1 and Weight Loss
 Disease Models, Animal Antibodies  >9 publications with MCHR1 and Disease Models, Animal
 Brain Diseases Antibodies  >9 publications with MCHR1 and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with MCHR1 and Nervous System Diseases
 Mood Disorders Antibodies  >7 publications with MCHR1 and Mood Disorders
 Inflammation Antibodies  >3 publications with MCHR1 and Inflammation
 Learning Disorders Antibodies  >3 publications with MCHR1 and Learning Disorders
 Liver Diseases Antibodies  >2 publications with MCHR1 and Liver Diseases
 Neoplasms Antibodies  >2 publications with MCHR1 and Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with MCHR1 and Congenital Abnormalities

Organs/Tissues associated with anti-MCHR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with MCHR1 and Brain
 Liver Antibodies  >10 publications with MCHR1 and Liver
 Kidney Antibodies  >7 publications with MCHR1 and Kidney
 Testis Antibodies  >1 publications with MCHR1 and Testis
 Pancreas Antibodies  >1 publications with MCHR1 and Pancreas
 Uncharacterized Tissue Antibodies  >1 publications with MCHR1 and Uncharacterized Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000