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RGS19 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648288

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RGS19, Polyclonal Antibody
Full Product Name
RGS19, NT (RGS19, GAIP, GNAI3IP, Regulator of G-protein signaling 19, G-alpha-interacting protein)
Product Gene Name
anti-RGS19 antibody
Product Synonym Names
Anti -RGS19, NT (RGS19, GAIP, GNAI3IP, Regulator of G-protein signaling 19, G-alpha-interacting protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,636 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (62704534..62711356, complement). Location: 20q13.33
OMIM
605071
3D Structure
ModBase 3D Structure for P49795
Immunogen
RGS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-term of human RGS19.

Product Categories/Family for anti-RGS19 antibody

Antibodies; Abs to G Proteins
Applications Tested/Suitable for anti-RGS19 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RGS19 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100 (Ref.1)
Immunohistochemistry: 1:50-100

Other Notes

Small volumes of anti-RGS19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS19 purchase

MBS648288 is an antibody targeting RGS19. Also known as RGS19, NT (RGS19, GAIP, GNAI3IP, Regulator of G-protein signaling 19, G-alpha-interacting protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS19. It may not necessarily be applicable to this product.

NCBI GI #
86990435
NCBI GeneID
10287
NCBI Accession #
NP_001034556.1
UniProt Primary Accession #
P49795
UniProt Secondary Accession #
Q53XN0; Q8TD60; A8K216; E1P5G9
UniProt Related Accession #
P49795
GenBank Nucleotide #
NM_001039467.1
NCBI Official Full Name
regulator of G-protein signaling 19
NCBI Official Synonym Full Names
regulator of G-protein signaling 19
NCBI Official Symbol
RGS19
NCBI Official Synonym Symbols
GAIP; RGSGAIP
UniProt Protein Name
Regulator of G-protein signaling 19
UniProt Synonym Protein Names
G-alpha-interacting protein
Protein Family
Regulator of G-protein signaling
UniProt Gene Name
RGS19
UniProt Synonym Gene Names
GAIP; GNAI3IP; RGS19; GAIP
UniProt Entry Name
RGS19_HUMAN
NCBI Protein Information
regulator of G-protein signaling 19; G alpha interacting protein; G-alpha-interacting protein; G protein signalling regulator 19; regulator of G-protein signalling 19; guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein

NCBI Summary for RGS19

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for RGS19

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Subunit structure: Interacts with GIPC PDZ domain.

Subcellular location: Membrane; Lipid-anchor.

Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Post-translational modification: Fatty acylated. Heavily palmitoylated in the cysteine string motif. Ref.8Phosphorylated, mainly on serine residues. Ref.12

Sequence similarities: Contains 1 RGS domain.
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Research Articles on RGS19

1. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RGS19 antibody

 Reference Product  PubMed Publications
 GIPC1 antibody  >6 publications with RGS19 and GIPC1
 DRD2 antibody  >1 publications with RGS19 and DRD2
 OPRL1 antibody  >1 publications with RGS19 and OPRL1
 GNAI3 antibody  >1 publications with RGS19 and GNAI3

Pathways associated with anti-RGS19 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-RGS19 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with RGS19 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with RGS19 and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >1 publications with RGS19 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with RGS19 and Heart Defects, Congenital
 Hypertension Antibodies  >1 publications with RGS19 and Hypertension

Organs/Tissues associated with anti-RGS19 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with RGS19 and Blood
 Bone Antibodies  >3 publications with RGS19 and Bone
 Lung Antibodies  >3 publications with RGS19 and Lung
 Kidney Antibodies  >2 publications with RGS19 and Kidney
 Brain Antibodies  >2 publications with RGS19 and Brain
 Heart Antibodies  >1 publications with RGS19 and Heart
 Embryonic Tissue Antibodies  >1 publications with RGS19 and Embryonic Tissue
 Eye Antibodies  >1 publications with RGS19 and Eye
 Prostate Antibodies  >1 publications with RGS19 and Prostate
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