FGD2 Antibody – Rabbit Polyclonal

Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Ref.2

Subcellular location: Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection › ruffle membrane. Cytoplasm › cytoskeleton

Probable. Note: Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Ref.2

Tissue specificity: Lymph node, spleen, B-lymphocytes and macrophages (at protein level). Expressed at high levels in lymph node, spleen, B-lymphocytes and bone marrow macrophages. Expressed at lower levels in mature bone marrow dendritic cells. In both immature and mature B-cells, expression is down-regulated by prior B-cell receptor signaling. Expression remains high in resting B and memory cells but declines upon differentiation into plasma cells. Ref.1 Ref.2

Domain: The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. Ref.2The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. Ref.2The DH domain is necessary for its ability to activate JNK1 via CDC42. Ref.2

Sequence similarities: Contains 1 DH (DBL-homology) domain.Contains 1 FYVE-type zinc finger.Contains 2 PH domains.

Sequence caution: The sequence AAC35430.1 differs from that shown. Reason: Frameshift at position 606. The sequence AAP45200.1 differs from that shown. Reason: Erroneous gene model prediction.