Mouse Anti-LRRFIP1 Polyclonal Antibody – Cat# MBS648335

Western Blot analysis of LRRFIP1 expression in transfected 293T cell line by LRRFIP1 polyclonal antibody. Lane 1: LRRFIP1 transfected lysate (12.2kD). Lane 2: Non-transfected lysate.

LRRFIP1 Antibody – Mouse Polyclonal

Name: LRRFIP1 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648335
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648335

Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with beta-catenin and activates beta-catenin-dependent… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LRRFIP1, Polyclonal Antibody

Full Product Name

LRRFIP1 (Leucine-rich Repeat Flightless-interacting Protein 1, LRR FLII-interacting Protein 1, GC-binding Factor 2, TAR RNA-interacting Protein, GCF2, TRIP)

Product Gene Name

anti-LRRFIP1 antibody

Product Synonym Names

Anti -LRRFIP1 (Leucine-rich Repeat Flightless-interacting Protein 1, LRR FLII-interacting Protein 1, GC-binding Factor 2, TAR RNA-interacting Protein, GCF2, TRIP)

Immunogen Sequence

MHVMDLQRDA NRQISDLKFK LAKSEQEITA LEQNVIRLES QVSRYKSAAE NAEKIEDELK AEKRKLQREL RSALDKTEEL EVSNGHLVKR LEKMKANRSA LLSQQ

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human LRRFIP1.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

89,253 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (238536224..238690290). Location: 2q37.3

OMIM

603256

3D Structure

ModBase 3D Structure for Q32MZ4

Immunogen

Full length human LRRFIP1, aa1-105 (AAH10662.1)

Product Categories/Family for anti-LRRFIP1 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-LRRFIP1 antibody

Western Blot (WB)

Application Notes for anti-LRRFIP1 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-LRRFIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRFIP1 purchase

MBS648335 is an antibody targeting LRRFIP1. Also known as LRRFIP1 (Leucine-rich Repeat Flightless-interacting Protein 1, LRR FLII-interacting Protein 1, GC-binding Factor 2, TAR RNA-interacting Protein, GCF2, TRIP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LRRFIP1. It may not necessarily be applicable to this product.

NCBI GI #

212276104

NCBI GeneID

9208

NCBI Accession #

NP_001131025.1

UniProt Primary Accession #

Q32MZ4

UniProt Secondary Accession #

O75766; O75799; Q32MZ5; Q53T49; Q6PKG2; Q9Y607; E9PGZ2

UniProt Related Accession #

Q32MZ4

GenBank Nucleotide #

NM_001137553.1

NCBI Official Full Name

leucine-rich repeat flightless-interacting protein 1 isoform 5

NCBI Official Synonym Full Names

leucine rich repeat (in FLII) interacting protein 1

NCBI Official Symbol

LRRFIP1

NCBI Official Synonym Symbols

GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1

UniProt Protein Name

Leucine-rich repeat flightless-interacting protein 1

UniProt Synonym Protein Names

GC-binding factor 2; TAR RNA-interacting protein

Protein Family

Leucine-rich repeat flightless-interacting protein

UniProt Gene Name

LRRFIP1

UniProt Synonym Gene Names

GCF2; TRIP; LRR FLII-interacting protein 1

UniProt Entry Name

LRRF1_HUMAN

NCBI Protein Information

leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1

UniProt Comments for LRRFIP1

Function: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Ref.1 Ref.6 Ref.7 Ref.8 Ref.13

Subunit structure: Homodimer. May also form higher oligomers. Interacts with FLII. Interacts with MYD88. Competes with FLII for MyD88-binding, even in the absence of LPS. Ref.2 Ref.13 Ref.18

Subcellular location: Nucleus. Cytoplasm Ref.2 Ref.7.

Tissue specificity: Ubiquitously expressed. Ref.1 Ref.2

Developmental stage: Widely expressed in fetal tissues. Ref.2

Domain: The DNA-binding domain is intrinsically unstructured. Ref.18The coiled coil mediates dimerization. Ref.18

Sequence similarities: Belongs to the LRRFIP family.

Sequence caution: The sequence AAH01385.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence AAY14672.1 differs from that shown. Reason: Erroneous gene model prediction.

Research Articles on LRRFIP1

1. Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LRRFIP1 antibody

Reference Product	PubMed Publications
FLII antibody	>4 publications with LRRFIP1 and FLII
CTNNB1 antibody	>3 publications with LRRFIP1 and CTNNB1
MYD88 antibody	>2 publications with LRRFIP1 and MYD88
TFAP2A antibody	>1 publications with LRRFIP1 and TFAP2A
SLC1A2 antibody	>1 publications with LRRFIP1 and SLC1A2
GRIP1 antibody	>1 publications with LRRFIP1 and GRIP1

Pathways associated with anti-LRRFIP1 antibody

Products by Pathway	Pathway Diagram
Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies	Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway antibodies	LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway Diagram
Signaling By FGFR In Disease Pathway antibodies	Signaling By FGFR In Disease Pathway Diagram
Signaling By FGFR Mutants Pathway antibodies	Signaling By FGFR Mutants Pathway Diagram
Signaling By FGFR1 Fusion Mutants Pathway antibodies	Signaling By FGFR1 Fusion Mutants Pathway Diagram
Signaling By FGFR1 Mutants Pathway antibodies	Signaling By FGFR1 Mutants Pathway Diagram

Diseases associated with anti-LRRFIP1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>5 publications with LRRFIP1 and Cardiovascular Diseases
Neoplasms Antibodies	>4 publications with LRRFIP1 and Neoplasms
Heart Diseases Antibodies	>3 publications with LRRFIP1 and Heart Diseases
Inflammation Antibodies	>3 publications with LRRFIP1 and Inflammation
Thrombosis Antibodies	>2 publications with LRRFIP1 and Thrombosis
Necrosis Antibodies	>2 publications with LRRFIP1 and Necrosis
Stroke Antibodies	>1 publications with LRRFIP1 and Stroke
Breast Neoplasms Antibodies	>1 publications with LRRFIP1 and Breast Neoplasms
Nervous System Diseases Antibodies	>1 publications with LRRFIP1 and Nervous System Diseases
Atherosclerosis Antibodies	>1 publications with LRRFIP1 and Atherosclerosis

Organs/Tissues associated with anti-LRRFIP1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with LRRFIP1 and Blood
Heart Antibodies	>4 publications with LRRFIP1 and Heart
Brain Antibodies	>3 publications with LRRFIP1 and Brain
Muscle Antibodies	>3 publications with LRRFIP1 and Muscle
Adipose Tissue Antibodies	>2 publications with LRRFIP1 and Adipose Tissue
Vascular Antibodies	>1 publications with LRRFIP1 and Vascular
Connective Tissue Antibodies	>1 publications with LRRFIP1 and Connective Tissue
Testis Antibodies	>1 publications with LRRFIP1 and Testis
Bone Marrow Antibodies	>1 publications with LRRFIP1 and Bone Marrow
Bone Antibodies	>1 publications with LRRFIP1 and Bone