Rabbit Anti-KLHL2 Polyclonal Antibody – Cat# MBS648387

KLHL2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KLHL2 antibody detected the KLHL2 protein (arrow).

KLHL2 Antibody – Rabbit Polyclonal

Name: KLHL2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648387
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648387

MBS648387 is an antibody targeting KLHL2. Also known as KLHL2, NT (KLHL2, Kelch-like protein 2, Actin-binding protein Mayven). Reactive in Human. Host: Rabbit. KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KLHL2, Polyclonal Antibody

Full Product Name

KLHL2, NT (KLHL2, Kelch-like protein 2, Actin-binding protein Mayven)

Product Gene Name

anti-KLHL2 antibody

Product Synonym Names

Anti -KLHL2, NT (KLHL2, Kelch-like protein 2, Actin-binding protein Mayven)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

65,975 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (166128770..166244308). Location: 4q21.2

OMIM

605774

3D Structure

ModBase 3D Structure for O95198

Immunogen

KLHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the N-terminal region of human KLHL2.

Product Categories/Family for anti-KLHL2 antibody

Antibodies; Abs to Actin Related Proteins

Applications Tested/Suitable for anti-KLHL2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-KLHL2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-KLHL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLHL2. It may not necessarily be applicable to this product.

NCBI GI #

239835720

NCBI GeneID

11275

NCBI Accession #

NP_009177.3

UniProt Primary Accession #

O95198

UniProt Secondary Accession #

Q8N484; Q8TBH5; A6NCM7; B4DFH7; F5H6M3

UniProt Related Accession #

O95198

GenBank Nucleotide #

NM_007246.3

NCBI Official Full Name

kelch-like protein 2 isoform 1

NCBI Official Synonym Full Names

kelch-like family member 2

NCBI Official Symbol

KLHL2

NCBI Official Synonym Symbols

MAV; MAYVEN; ABP-KELCH

UniProt Protein Name

Kelch-like protein 2

UniProt Synonym Protein Names

Actin-binding protein Mayven

Protein Family

Kelch-like protein

UniProt Gene Name

KLHL2

UniProt Entry Name

KLHL2_HUMAN

NCBI Protein Information

kelch-like protein 2; kelch-like 2, Mayven; actin-binding protein Mayven

UniProt Comments for KLHL2

Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation

By similarity. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. Ref.6

Subunit structure: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with NPTXR and CUL3

By similarity. Binds actin. Interacts with KLHL12. Interacts (via N-terminus) with FYN (via SH3 domain). Ref.1 Ref.5 Ref.6

Subcellular location: Cytoplasm › cytoskeleton. Cell projection › ruffle. Cell projection

By similarity. Cell projection › lamellipodium

By similarity. Cytoplasm › cytosol. Note: A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes

By similarity. Ref.1 Ref.6

Tissue specificity: Ubiquitous. Detected throughout the brain. Ref.1

Sequence similarities: Contains 1 BTB (POZ) domain.Contains 6 Kelch repeats.

Research Articles on KLHL2

1. Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLHL2 antibody

Reference Product	PubMed Publications
CUL3 antibody	>2 publications with KLHL2 and CUL3
JUN antibody	>2 publications with KLHL2 and JUN

Diseases associated with anti-KLHL2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with KLHL2 and Neoplasms
Nervous System Diseases Antibodies	>2 publications with KLHL2 and Nervous System Diseases
Breast Neoplasms Antibodies	>1 publications with KLHL2 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with KLHL2 and Neoplasms, Experimental

Organs/Tissues associated with anti-KLHL2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with KLHL2 and Brain
Blood Antibodies	>2 publications with KLHL2 and Blood
Embryonic Tissue Antibodies	>1 publications with KLHL2 and Embryonic Tissue