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ACKR4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648465

CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CCBP2 (ACKR4), Polyclonal Antibody
Full Product Name
CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9)
Product Gene Name
anti-ACKR4 antibody
Product Synonym Names
Anti -CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CCBP2. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,914 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (132316081..132321488). Location: 3q22
OMIM
606065
3D Structure
ModBase 3D Structure for Q9NPB9
Immunogen
Synthetic peptide selected from the N-terminal region of human CCBP2 (KLH).

Product Categories/Family for anti-ACKR4 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-ACKR4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACKR4 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-ACKR4 antibody

The anti-CCBP2 N-term Pab is used in Western blot to detect CCBP2 in mouse liver tissue lysate.
Rabbit Anti-ACKR4 Polyclonal Antibody – Cat# MBS648465

Immunohistochemistry (IHC) of anti-ACKR4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-ACKR4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648465

Other Notes

Small volumes of anti-ACKR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACKR4 purchase

MBS648465 is an antibody targeting ACKR4. Also known as CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACKR4. It may not necessarily be applicable to this product.

NCBI GI #
30795217
NCBI GeneID
51554
NCBI Accession #
NP_848540.1
UniProt Primary Accession #
Q9NPB9
UniProt Secondary Accession #
B2R9U7
UniProt Related Accession #
Q9NPB9
GenBank Nucleotide #
NM_178445.2
NCBI Official Full Name
C-C chemokine receptor type 11
NCBI Official Synonym Full Names
atypical chemokine receptor 4
NCBI Official Symbol
ACKR4
NCBI Official Synonym Symbols
PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
UniProt Protein Name
C-C chemokine receptor type 11
UniProt Synonym Protein Names
CC chemokine receptor-like 1; CCRL1; CCX CKR
Protein Family
Atypical chemokine receptor
UniProt Gene Name
CCRL1
UniProt Synonym Gene Names
CCBP2; CCR11; VSHK1; C-C CKR-11; CC-CKR-11; CCR-11; CCRL1
UniProt Entry Name
CCRL1_HUMAN
NCBI Protein Information
C-C chemokine receptor type 11; C-C CKR-11; CC chemokine receptor-like 1; chemocentryx chemokine receptor; chemokine (C-C motif) receptor-like 1; chemokine, cc motif, receptor-like protein 1; orphan seven-transmembrane receptor, chemokine related

NCBI Summary for ACKR4

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
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UniProt Comments for ACKR4

Function: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Ref.3

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. Ref.1 Ref.2 Ref.7

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
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Research Articles on ACKR4

1. co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACKR4 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
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