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MARK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648467

MARKL1, a MARK type protein kinase, contains a N-terminal serine/threonine kinase domain, a central ubiquitin-associated domain and a C-terminal KA1-associated kinase domain. A smaller mRNA transcript, lacking exon 16 containing the KA1-associated kinase… More details

$935 / 0.05 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MARK4, Polyclonal Antibody
Full Product Name
MARK4, ID (MAP/Microtubule Affinity-regulating Kinase 4, KIAA1860, MAP/Microtubule Affinity-regulating Kinase-like 1, MARKL1)
Product Gene Name
anti-MARK4 antibody
Product Synonym Names
Anti -MARK4, ID (MAP/Microtubule Affinity-regulating Kinase 4, KIAA1860, MAP/Microtubule Affinity-regulating Kinase-like 1, MARKL1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human MARK4. Species sequence homology: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
82,520 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (45754516..45808541). Location: 19q13.3
OMIM
606495
3D Structure
ModBase 3D Structure for Q96L34
Immunogen
Synthetic peptide corresponding to human MARK4.

Product Categories/Family for anti-MARK4 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-MARK4 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MARK4 antibody
Suitable for use in ELISA, Immunofluorescence and Immunohistochemistry.
Dilution: ELISA: 1:40,000
Immunofluorescence: 1:100-1:500
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml

Immunohistochemistry (IHC) of anti-MARK4 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-MARK4 Polyclonal Antibody – Cat# MBS648467

Immunofluorescence (IF) of anti-MARK4 antibody

Immunofluorescence analysis of A549 cells, using MARK4 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-MARK4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS648467

Other Notes

Small volumes of anti-MARK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MARK4 purchase

MBS648467 is an antibody targeting MARK4. Also known as MARK4, ID (MAP/Microtubule Affinity-regulating Kinase 4, KIAA1860, MAP/Microtubule Affinity-regulating Kinase-like 1, MARKL1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MARK4. It may not necessarily be applicable to this product.

NCBI GI #
315467849
NCBI GeneID
57787
NCBI Accession #
NP_001186796.1
UniProt Primary Accession #
Q96L34
UniProt Secondary Accession #
Q8NG37; Q96JG7; Q96SQ2; Q9BYD8
UniProt Related Accession #
Q96L34
GenBank Nucleotide #
NM_001199867.1
NCBI Official Full Name
MAP/microtubule affinity-regulating kinase 4 isoform 1
NCBI Official Synonym Full Names
MAP/microtubule affinity-regulating kinase 4
NCBI Official Symbol
MARK4
NCBI Official Synonym Symbols
MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L
UniProt Protein Name
MAP/microtubule affinity-regulating kinase 4
UniProt Synonym Protein Names
MAP/microtubule affinity-regulating kinase-like 1
Protein Family
MAP/microtubule affinity-regulating kinase
UniProt Gene Name
MARK4
UniProt Synonym Gene Names
KIAA1860; MARKL1
UniProt Entry Name
MARK4_HUMAN
NCBI Protein Information
MAP/microtubule affinity-regulating kinase 4; MARK4 serine/threonine protein kinase; MAP/microtubule affinity-regulating kinase like 1

NCBI Summary for MARK4

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for MARK4

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Activated by phosphorylation on Thr-214. Ref.6

Tissue specificity: Ubiquitous. Isoform 2 is brain-specific. Ref.2

Post-translational modification: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X. Ref.7Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Ref.6

Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Contains 1 KA1 (kinase-associated) domain.Contains 1 protein kinase domain.Contains 1 UBA domain.

Sequence caution: The sequence BAB47489.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55238.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on MARK4

1. MARK4 is a critical positive regulator of early steps in ciliogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MARK4 antibody

 Reference Product  PubMed Publications
 MARK2 antibody  >14 publications with MARK4 and MARK2
 STK11 antibody  >4 publications with MARK4 and STK11
 USP9X antibody  >3 publications with MARK4 and USP9X

Pathways associated with anti-MARK4 antibody

 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram

Diseases associated with anti-MARK4 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with MARK4 and Disease Models, Animal
 Diabetes Mellitus, Type 2 Antibodies  >2 publications with MARK4 and Diabetes Mellitus, Type 2
 Colonic Neoplasms Antibodies  >1 publications with MARK4 and Colonic Neoplasms
 Adenoma Antibodies  >1 publications with MARK4 and Adenoma
 Immune System Diseases Antibodies  >1 publications with MARK4 and Immune System Diseases
 Liver Diseases Antibodies  >1 publications with MARK4 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with MARK4 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with MARK4 and Liver Neoplasms
 Liver Neoplasms, Experimental Antibodies  >1 publications with MARK4 and Liver Neoplasms, Experimental
 Hypertrophy Antibodies  >1 publications with MARK4 and Hypertrophy

Organs/Tissues associated with anti-MARK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with MARK4 and Brain
 Blood Antibodies  >10 publications with MARK4 and Blood
 Muscle Antibodies  >8 publications with MARK4 and Muscle
 Liver Antibodies  >8 publications with MARK4 and Liver
 Heart Antibodies  >5 publications with MARK4 and Heart
 Stomach Antibodies  >3 publications with MARK4 and Stomach
 Kidney Antibodies  >2 publications with MARK4 and Kidney
 Vascular Antibodies  >1 publications with MARK4 and Vascular
 Mammary Gland Antibodies  >1 publications with MARK4 and Mammary Gland
 Lung Antibodies  >1 publications with MARK4 and Lung
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