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URGCP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648497

URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
URG4 (URGCP), Polyclonal Antibody
Full Product Name
URG4, ID (URGCP, KIAA1507, URG4, Up-regulator of cell proliferation, HBV X protein up-regulated gene 4 protein, HBxAg up-regulated gene 4 protein)
Product Gene Name
anti-URGCP antibody
Product Synonym Names
Anti -URG4, ID (URGCP, KIAA1507, URG4, Up-regulator of cell proliferation, HBV X protein up-regulated gene 4 protein, HBxAg up-regulated gene 4 protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
104,987 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (43915485..43965996, complement). Location: 7p13
OMIM
610337
3D Structure
ModBase 3D Structure for Q8TCY9
Immunogen
URG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473~503 amino acids from the Central region of human URG4.

Product Categories/Family for anti-URGCP antibody

Antibodies; Abs to KIAA; orf
Applications Tested/Suitable for anti-URGCP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-URGCP antibody
Suitable for use in Western Blot, Immunohistochemistry
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-URGCP antibody

Western blot analysis of URG4 Antibody (Center) in CEM cell line lysates (35ug/lane). URG4 (arrow) was detected using the purified Pab.
Rabbit Anti-URGCP Polyclonal Antibody – Cat# MBS648497

Immunohistochemistry (IHC) of anti-URGCP antibody

URG4 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the URG4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-URGCP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648497

Other Notes

Small volumes of anti-URGCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for URGCP purchase

MBS648497 is an antibody targeting URGCP. Also known as URG4, ID (URGCP, KIAA1507, URG4, Up-regulator of cell proliferation, HBV X protein up-regulated gene 4 protein, HBxAg up-regulated gene 4 protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for URGCP. It may not necessarily be applicable to this product.

NCBI GI #
117968347
NCBI GeneID
55665
NCBI Accession #
NP_060390.3
UniProt Primary Accession #
Q8TCY9
UniProt Secondary Accession #
Q658M4; Q68DH6; Q6MZZ5; Q8WV98; Q9NWR7; Q9P221; E9PFF6
UniProt Related Accession #
Q8TCY9
GenBank Nucleotide #
NM_017920.3
NCBI Official Full Name
up-regulator of cell proliferation isoform 1
NCBI Official Synonym Full Names
upregulator of cell proliferation
NCBI Official Symbol
URGCP
NCBI Official Synonym Symbols
URG4
UniProt Protein Name
Up-regulator of cell proliferation
UniProt Synonym Protein Names
HBV X protein up-regulated gene 4 protein; HBxAg up-regulated gene 4 protein
Protein Family
Up-regulator of cell proliferation
UniProt Gene Name
URGCP
UniProt Synonym Gene Names
KIAA1507; URG4
UniProt Entry Name
URGCP_HUMAN
NCBI Protein Information
up-regulator of cell proliferation; up-regulated gene 4; HBxAg up-regulated gene 4 protein; HBV X protein up-regulated gene 4 protein

NCBI Summary for URGCP

URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]

UniProt Comments for URGCP

Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. Ref.1 Ref.7

Subcellular location: Cytoplasm. Nucleus. Note: In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. Ref.1 Ref.7

Tissue specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines. Ref.1 Ref.7

Induction: By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level). Ref.1 Ref.7

Sequence caution: The sequence BAA91312.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA96031.1 differs from that shown. Reason: Erroneous initiation. The sequence CAE45880.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH18244.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAH18244.1 differs from that shown. Reason: Frameshift at position 5.
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Research Articles on URGCP

1. Rapamycin diminishes URGCP gene expression in DU145 and PC3 cells, but increases expression in LNCaP cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-URGCP antibody

 Reference Product  PubMed Publications
 CCND1 antibody  >1 publications with URGCP and CCND1

Diseases associated with anti-URGCP antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with URGCP and Liver Diseases

Organs/Tissues associated with anti-URGCP antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with URGCP and Liver
 Prostate Antibodies  >1 publications with URGCP and Prostate
 Bone Antibodies  >1 publications with URGCP and Bone
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