Mouse Anti-TBCC Monoclonal Antibody – Cat# MBS648557

Detection limit for recombinant GST tagged TBCC is 0.3ng/ml as a capture antibody.

TBCC Antibody – Mouse Monoclonal

Name: TBCC Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648557
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648557

Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in… More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TBCC, Monoclonal Antibody

Full Product Name

TBCC (Tubulin-specific Chaperone C, Tubulin-folding Cofactor C, CFC)

Product Gene Name

anti-TBCC antibody

Product Synonym Names

Anti -TBCC (Tubulin-specific Chaperone C, Tubulin-folding Cofactor C, CFC)

Immunogen Sequence

MESVSCSAAA VRTGDMESQR DLSLVPERLQ RREQERQLEV ERRKQKRQNQ EVEKENSHFF VATFARERAA VEELLERAES VERLEEAASR LQGLQKLIND SVFFLAAYDL RQGQEALARL QAALAERRRG LQPKKRFAFK TRGKDAASST KVDAAPGIPP AVESIQDSPL PKKAEGDLGP SWVCGFSNLE SQVLEKRASE LHQRDVLLTE LSNCTVRLYG NPNTLRLTKA HSCKLLCGPV STSVFLEDCS DCVLAVACQQ LRIHSTKDTR IFLQVTSRAI VEDCSGIQFA PYTWSYPEID KDFESSGLDR SKNNWNDVDD FNWLARDMAS PNWSILPEEE RNIQWD

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

3D3

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human TBCC.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

39,248 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (42712234..42713884, complement). Location: 6p21.1

OMIM

602971

3D Structure

ModBase 3D Structure for Q15814

Immunogen

Full length recombinant corresponding to aa1-347 from human TBCC (AAH20170) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TBCC antibody

Antibodies; Abs to Tubulin

Applications Tested/Suitable for anti-TBCC antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TBCC antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-TBCC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBCC purchase

MBS648557 is an antibody targeting TBCC. Also known as TBCC (Tubulin-specific Chaperone C, Tubulin-folding Cofactor C, CFC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TBCC. It may not necessarily be applicable to this product.

NCBI GI #

4507373

NCBI GeneID

6903

NCBI Accession #

NP_003183.1

UniProt Primary Accession #

Q15814

UniProt Secondary Accession #

Q53Y43; Q5T787

UniProt Related Accession #

Q15814

GenBank Nucleotide #

NM_003192.2

NCBI Official Full Name

tubulin-specific chaperone C

NCBI Official Synonym Full Names

tubulin folding cofactor C

NCBI Official Symbol

TBCC

NCBI Official Synonym Symbols

CFC

UniProt Protein Name

Tubulin-specific chaperone C

UniProt Synonym Protein Names

Tubulin-folding cofactor C

Protein Family

TBCC domain-containing protein

UniProt Gene Name

TBCC

UniProt Synonym Gene Names

CFC

UniProt Entry Name

TBCC_HUMAN

NCBI Protein Information

tubulin-specific chaperone C; tubulin-folding cofactor C

UniProt Comments for TBCC

Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Ref.6

Subunit structure: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

Subcellular location: Cytoplasm. Note: Detected predominantly in the photoreceptor connecting cilium. Ref.7

Tissue specificity: Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL). Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level). Ref.7

Sequence similarities: Belongs to the TBCC family.Contains 1 C-CAP/cofactor C-like domain.

Research Articles on TBCC

1. a testable model for TBCC N-terminal domain/tubulin recognition in which the highly charged N-terminus as well as residues from the three helices and the loops interact with the acidic hypervariable regions of tubulin monomers

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBCC antibody

Reference Product	PubMed Publications
TBCE antibody	>5 publications with TBCC and TBCE
TBCD antibody	>5 publications with TBCC and TBCD
ARL3 antibody	>1 publications with TBCC and ARL3

Pathways associated with anti-TBCC antibody

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-chaperonin Tubulin Folding Pathway antibodies	Post-chaperonin Tubulin Folding Pathway Diagram
Protein Folding Pathway antibodies	Protein Folding Pathway Diagram

Diseases associated with anti-TBCC antibody

Disease Name	Pubmed Publications
Retinal Degeneration Antibodies	>1 publications with TBCC and Retinal Degeneration

Organs/Tissues associated with anti-TBCC antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>10 publications with TBCC and Liver
Blood Antibodies	>7 publications with TBCC and Blood
Eye Antibodies	>3 publications with TBCC and Eye
Intestine Antibodies	>3 publications with TBCC and Intestine
Muscle Antibodies	>3 publications with TBCC and Muscle
Adrenal Gland Antibodies	>1 publications with TBCC and Adrenal Gland
Bone Antibodies	>1 publications with TBCC and Bone
Connective Tissue Antibodies	>1 publications with TBCC and Connective Tissue
Lung Antibodies	>1 publications with TBCC and Lung