MIEN1 Antibody – Mouse Monoclonal

Function: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. Ref.6 Ref.8

Subunit structure: Interacts with GPX1

By similarity.

Subcellular location: Cytoplasm › cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note: Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions. Ref.1 Ref.6 Ref.8

Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level). Ref.1 Ref.6

Post-translational modification: Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.

Sequence similarities: Belongs to the SelWTH family.