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ZBTB7A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648583

ZBTB7A plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates… More details

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Product Overview

Online Datasheet in PDF
Product Name
ZBTB7A, Polyclonal Antibody
Full Product Name
ZBTB7A, CT (ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A, Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ
Product Gene Name
anti-ZBTB7A antibody
Product Synonym Names
Anti -ZBTB7A, CT (ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A, Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
61,439 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (4045216..4066816, complement). Location: 19p13.3
OMIM
605878
3D Structure
ModBase 3D Structure for O95365
Immunogen
ZBTB7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-542 amino acids from the C-terminal region of human ZBTB7A.

Product Categories/Family for anti-ZBTB7A antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-ZBTB7A antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ZBTB7A antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-ZBTB7A antibody

ZBTB7A Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ZBTB7A antibody detected the ZBTB7A protein (arrow).
Rabbit Anti-ZBTB7A Polyclonal Antibody – Cat# MBS648583

Immunohistochemistry (IHC) of anti-ZBTB7A antibody

ZBTB7A Antibody (C-term) (AP14208b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZBTB7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ZBTB7A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648583

Other Notes

Small volumes of anti-ZBTB7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZBTB7A purchase

MBS648583 is an antibody targeting ZBTB7A. Also known as ZBTB7A, CT (ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A, Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZBTB7A. It may not necessarily be applicable to this product.

NCBI GI #
7705375
NCBI GeneID
51341
NCBI Accession #
NP_056982.1
UniProt Primary Accession #
O95365
UniProt Secondary Accession #
O00456; Q14D41; Q5XG86; D6W619
UniProt Related Accession #
O95365
GenBank Nucleotide #
NM_015898.2
NCBI Official Full Name
zinc finger and BTB domain-containing protein 7A
NCBI Official Synonym Full Names
zinc finger and BTB domain containing 7A
NCBI Official Symbol
ZBTB7A
NCBI Official Synonym Symbols
LRF; FBI1; FBI-1; ZBTB7; ZNF857A; pokemon
UniProt Protein Name
Zinc finger and BTB domain-containing protein 7A
UniProt Synonym Protein Names
Factor binding IST protein 1; FBI-1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon; TTF-I-interacting peptide 21; TIP21; Zinc finger protein 857A
Protein Family
Zinc finger and BTB domain-containing protein
UniProt Gene Name
ZBTB7A
UniProt Synonym Gene Names
FBI1; LRF; ZBTB7; ZNF857A; FBI-1; POK erythroid myeloid ontogenic factor; Pokemon; TIP21
UniProt Entry Name
ZBT7A_HUMAN
NCBI Protein Information
zinc finger and BTB domain-containing protein 7A; TIP21; lymphoma related factor; zinc finger protein 857A; HIV-1 1st-binding protein 1; TTF-I-interacting peptide 21; factor binding IST protein 1; leukemia/lymphoma-related factor; POK erythroid myeloid ontogenic factor; HIV-1 inducer of short transcripts binding protein; POZ and Krueppel erythroid myeloid ontogenic factor; factor that binds to inducer of short transcripts protein 1; zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein

UniProt Comments for ZBTB7A

Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals

By similarity. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'

By similarity.

Subunit structure: Interacts with BCL6

By similarity.

Subcellular location: Nucleus

By similarity.

Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). Ref.5 Ref.6

Sequence similarities: Contains 1 BTB (POZ) domain.Contains 4 C2H2-type zinc fingers.

Sequence caution: The sequence AAB58414.1 differs from that shown. Reason: Frameshift at positions 8 and 324.
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Research Articles on ZBTB7A

1. Knockdown of Pokemon protein expression inhibits hepatocellular carcinoma cell proliferation by suppression of AKT activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZBTB7A antibody

 Reference Product  PubMed Publications
 SP1 antibody  >10 publications with ZBTB7A and SP1
 BCL6 antibody  >5 publications with ZBTB7A and BCL6
 TP53 antibody  >3 publications with ZBTB7A and TP53
 HDAC1 antibody  >2 publications with ZBTB7A and HDAC1
 BCOR antibody  >2 publications with ZBTB7A and BCOR
 BIRC5 antibody  >1 publications with ZBTB7A and BIRC5
 EEF1A1 antibody  >1 publications with ZBTB7A and EEF1A1
 NCOR2 antibody  >1 publications with ZBTB7A and NCOR2

Diseases associated with anti-ZBTB7A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >39 publications with ZBTB7A and Neoplasms
 Carcinoma Antibodies  >17 publications with ZBTB7A and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >9 publications with ZBTB7A and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with ZBTB7A and Liver Neoplasms
 Liver Diseases Antibodies  >8 publications with ZBTB7A and Liver Diseases
 Prostatic Neoplasms Antibodies  >7 publications with ZBTB7A and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >5 publications with ZBTB7A and Lung Neoplasms
 Inflammation Antibodies  >2 publications with ZBTB7A and Inflammation
 Brain Diseases Antibodies  >1 publications with ZBTB7A and Brain Diseases
 Hyperplasia Antibodies  >1 publications with ZBTB7A and Hyperplasia

Organs/Tissues associated with anti-ZBTB7A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with ZBTB7A and Blood
 Bone Antibodies  >10 publications with ZBTB7A and Bone
 Prostate Antibodies  >8 publications with ZBTB7A and Prostate
 Lung Antibodies  >6 publications with ZBTB7A and Lung
 Brain Antibodies  >5 publications with ZBTB7A and Brain
 Connective Tissue Antibodies  >4 publications with ZBTB7A and Connective Tissue
 Thymus Antibodies  >4 publications with ZBTB7A and Thymus
 Bone Marrow Antibodies  >4 publications with ZBTB7A and Bone Marrow
 Lymph Node Antibodies  >4 publications with ZBTB7A and Lymph Node
 Embryonic Tissue Antibodies  >3 publications with ZBTB7A and Embryonic Tissue
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