DCTN2 Antibody – Mouse Polyclonal

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

Subunit structure: Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135

By similarity. Interacts with DYNAP, ECM29 and MAPRE1. Ref.9 Ref.13 Ref.14

Subcellular location: Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Membrane; Peripheral membrane protein Ref.1.

Sequence similarities: Belongs to the dynactin subunit 2 family.

Sequence caution: The sequence AAO34395.1 differs from that shown. Reason: Frameshift at position 381.