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OPA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648718

OPA1 (optic atrophy 1) is a dynamin-related GTPase that plays a role in genome preservation and mitochondrial morphology. Localization of OPA1 is thought to be anchored to the inner membrane of the mitochondria. OPA1 is highly expressed in inner and outer… More details

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Product Overview

Online Datasheet in PDF
Product Name
OPA1, Polyclonal Antibody
Full Product Name
OPA1 (Dynamin-like 120kD Protein, Mitochondrial, Optic Atrophy Protein 1, KIAA0567)
Product Gene Name
anti-OPA1 antibody
Product Synonym Names
Anti -OPA1 (Dynamin-like 120kD Protein, Mitochondrial, Optic Atrophy Protein 1, KIAA0567)
Immunogen Sequence
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFE KIRKALPSSE DLVKLAPDFD KIVESLSLLK DFFTSGSPEE TAFRATDRGS ESDKHFRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVASPS RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIEAIREYEE EFFQNSKLLK TSMLKAHQVT TRNLSLAVSD CFWKMVRESV EQQADSFKAT RFNLETEWKN NYPRLRELDR NELFEKAKNE ILDEVISLSQ VTPKHWEEIL QQSLWERVST HVIENIYLPA AQTMNSGTFN TTVDIKLKQW TDKQLPNKAV EVAWETLQEE FSRFMTEPKG KEHDDIFDKL KEAVKEESIK RHKWNDFAED SLRVIQHNAL EDRSISDKQQ WDAAIYFMEE ALQARLKDTE NAIENMVGPD WKKRWLYWKN RTQEQCVHNE TKNELEKMLK CNEEHPAYLA SDEITTVRKN LESRGVEVDP SLIKDTWHQV YRRHFLKTAL NHCNLCRRGF YYYQRHFVDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN TEVRRLEKNV KEVLEDFAED GEKKIKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human OPA1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
111,631 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (193310933..193415600). Location: 3q28-q29
OMIM
125250
3D Structure
ModBase 3D Structure for O60313
Immunogen
Full length human OPA1, aa1-960 (NP_056375.1).

Product Categories/Family for anti-OPA1 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-OPA1 antibody
Western Blot (WB)
Application Notes for anti-OPA1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-OPA1 antibody

OPA1 rabbit polyclonal antibody. Western Blot analysis of OPA1 expression in human colon.
Rabbit Anti-OPA1 Polyclonal Antibody – Cat# MBS648718

Western Blot (WB) of anti-OPA1 antibody

Western Blot analysis of OPA1 expression in transfected 293T cell line by OPA1 polyclonal antibody. Lane 1: OPA1 transfected lysate (111.6kD). Lane 2: Non-transfected lysate
Rabbit Anti-OPA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS648718

Other Notes

Small volumes of anti-OPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OPA1 purchase

MBS648718 is an antibody targeting OPA1. Also known as OPA1 (Dynamin-like 120kD Protein, Mitochondrial, Optic Atrophy Protein 1, KIAA0567). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OPA1. It may not necessarily be applicable to this product.

NCBI GI #
34783689
NCBI GeneID
4976
NCBI Accession #
AAH58013.1
UniProt Primary Accession #
O60313
UniProt Secondary Accession #
D3DNW4
UniProt Related Accession #
O60313
NCBI Official Full Name
OPA1 protein
NCBI Official Synonym Full Names
optic atrophy 1 (autosomal dominant)
NCBI Official Symbol
OPA1
NCBI Official Synonym Symbols
NPG; NTG; MGM1; largeG
UniProt Protein Name
Dynamin-like 120 kDa protein, mitochondrial
UniProt Synonym Protein Names
Optic atrophy protein 1
Protein Family
Dynamin-like 120 kDa protein
UniProt Gene Name
OPA1
UniProt Synonym Gene Names
KIAA0567
UniProt Entry Name
OPA1_HUMAN
NCBI Protein Information
dynamin-like 120 kDa protein, mitochondrial; optic atrophy protein 1; mitochondrial dynamin-like GTPase; dynamin-like guanosine triphosphatase

NCBI Summary for OPA1

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for OPA1

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance.
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Research Articles on OPA1

1. Our work expands the spectrum of mutation in OPA1, which may lead to severe multisystem neurological disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OPA1 antibody

 Reference Product  PubMed Publications
 MFN2 antibody  >77 publications with OPA1 and MFN2
 PARL antibody  >15 publications with OPA1 and PARL
 PHB2 antibody  >6 publications with OPA1 and PHB2
 TMEM126A antibody  >1 publications with OPA1 and TMEM126A
 CHCHD3 antibody  >1 publications with OPA1 and CHCHD3

Diseases associated with anti-OPA1 antibody

 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >217 publications with OPA1 and Mitochondrial Diseases
 Optic Atrophy, Autosomal Dominant Antibodies  >203 publications with OPA1 and Optic Atrophy, Autosomal Dominant
 Optic atrophy 1 and deafness Antibodies  >15 publications with OPA1 and Optic atrophy 1 and deafness
 Cardiovascular Diseases Antibodies  >10 publications with OPA1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >9 publications with OPA1 and Heart Diseases
 Weight Loss Antibodies  >6 publications with OPA1 and Weight Loss
 Carcinoma Antibodies  >6 publications with OPA1 and Carcinoma
 Necrosis Antibodies  >5 publications with OPA1 and Necrosis
 Hypertension Antibodies  >4 publications with OPA1 and Hypertension
 Inflammation Antibodies  >3 publications with OPA1 and Inflammation

Organs/Tissues associated with anti-OPA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >93 publications with OPA1 and Eye
 Brain Antibodies  >65 publications with OPA1 and Brain
 Muscle Antibodies  >61 publications with OPA1 and Muscle
 Blood Antibodies  >32 publications with OPA1 and Blood
 Heart Antibodies  >24 publications with OPA1 and Heart
 Skin Antibodies  >9 publications with OPA1 and Skin
 Liver Antibodies  >9 publications with OPA1 and Liver
 Embryonic Tissue Antibodies  >8 publications with OPA1 and Embryonic Tissue
 Ear Antibodies  >8 publications with OPA1 and Ear
 Vascular Antibodies  >7 publications with OPA1 and Vascular
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