KIF5C Antibody – Rabbit Polyclonal

The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]

Function: Mediates dendritic trafficking of mRNAs

By similarity. Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Subunit structure: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3

By similarity. Interacts with TRAK1. Ref.5

Subcellular location: Cytoplasm › cytoskeleton

Probable.

Tissue specificity: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.

Domain: Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similarities: Belongs to the kinesin-like protein family. Kinesin subfamily.Contains 1 kinesin-motor domain.

Sequence caution: The sequence BAA25457.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.