Rabbit Anti-GEMIN8 Polyclonal Antibody – Cat# MBS648752

GEMIN8 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GEMIN8 antibody detected the GEMIN8 protein (arrow).

GEMIN8 Antibody – Rabbit Polyclonal

Name: GEMIN8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648752
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648752

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GEMIN8, Polyclonal Antibody

Full Product Name

GEMIN8, CT (GEMIN8, FAM51A1, Gem-associated protein 8, Protein FAM51A1)

Product Gene Name

anti-GEMIN8 antibody

Product Synonym Names

Anti -GEMIN8, CT (GEMIN8, FAM51A1, Gem-associated protein 8, Protein FAM51A1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

28,637 Da

Chromosome Location

Chromosome: X; NC_000023.10 (14024845..14048035, complement). Location: Xp22.2

3D Structure

ModBase 3D Structure for Q9NWZ8

Immunogen

GEMIN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-239 amino acids from the C-terminal region of human GEMIN8.

Product Categories/Family for anti-GEMIN8 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-GEMIN8 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-GEMIN8 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-GEMIN8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GEMIN8 purchase

MBS648752 is an antibody targeting GEMIN8. Also known as GEMIN8, CT (GEMIN8, FAM51A1, Gem-associated protein 8, Protein FAM51A1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GEMIN8. It may not necessarily be applicable to this product.

NCBI GI #

109715864

NCBI GeneID

54960

NCBI Accession #

NP_001035944.1

UniProt Primary Accession #

Q9NWZ8

UniProt Secondary Accession #

Q2LJ66; Q6ZV27; C4AMC4

UniProt Related Accession #

Q9NWZ8

GenBank Nucleotide #

NM_001042479.1

NCBI Official Full Name

gem-associated protein 8

NCBI Official Synonym Full Names

gem (nuclear organelle) associated protein 8

NCBI Official Symbol

GEMIN8

NCBI Official Synonym Symbols

FAM51A1

UniProt Protein Name

Gem-associated protein 8

UniProt Synonym Protein Names

Protein FAM51A1

Protein Family

Gem-associated protein

UniProt Gene Name

GEMIN8

UniProt Synonym Gene Names

FAM51A1; Gemin-8

UniProt Entry Name

GEMI8_HUMAN

NCBI Protein Information

gem-associated protein 8; gemin-8; family with sequence similarity 51, member A1

NCBI Summary for GEMIN8

The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

UniProt Comments for GEMIN8

Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Ref.7

Subunit structure: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to SMN1 and to the GEMIN6-GEMIN7 heterodimer, mediating their interaction. Ref.1

Subcellular location: Nucleus › gem. Cytoplasm. Note: Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Ref.1

Sequence caution: The sequence BAC86038.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on GEMIN8

1. Gemin8 is a novel integral component of the SMN complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GEMIN8 antibody

Reference Product	PubMed Publications
GEMIN7 antibody	>4 publications with GEMIN8 and GEMIN7
GEMIN6 antibody	>3 publications with GEMIN8 and GEMIN6
GEMIN5 antibody	>1 publications with GEMIN8 and GEMIN5

Pathways associated with anti-GEMIN8 antibody

Products by Pathway	Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
Survival Motor Neuron (SMN) Complex Pathway antibodies	Survival Motor Neuron (SMN) Complex Pathway Diagram

Diseases associated with anti-GEMIN8 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with GEMIN8 and Nervous System Diseases

Organs/Tissues associated with anti-GEMIN8 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>1 publications with GEMIN8 and Muscle