NANOS1 Antibody – Rabbit Polyclonal

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Ref.2 Ref.4

Subunit structure: Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Ref.1 Ref.2 Ref.5

Subcellular location: Cytoplasm › perinuclear region. Cytoplasm. Note: Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. Ref.1 Ref.2 Ref.5

Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6

Developmental stage: Fetal ovary and fetal testis (at protein level). Ref.6

Induction: Down-regulated by E-cadherin. Ref.2

Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein

By similarity.The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.

Sequence similarities: Belongs to the nanos family.Contains 1 nanos-type zinc finger.