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MINK1, 2 (MINK) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6488206

MBS6488206 is an antibody targeting MINK. Also known as MINK1, 2, CT (Misshapen/NIK-related Kinase, Misshapen-like Kinase 1, MINK1, MINK, B55, GCK Family Kinase MiNK, hMINK, hMINKbeta, MAPK/ERK Kinase Kinase Kinase 6, MEK Kinase Kinase 6, MEKKK 6,… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MINK1, 2, Polyclonal Antibody
Full Product Name
MINK1, 2, CT (Misshapen/NIK-related Kinase, Misshapen-like Kinase 1, MINK1, MINK, B55, GCK Family Kinase MiNK, hMINK, hMINKbeta, MAPK/ERK Kinase Kinase Kinase 6, MEK Kinase Kinase 6, MEKKK 6, Mitogen-activated Protein Kinase Kinase Kinase Kinase 6, MAP4K6
Product Gene Name
anti-MINK antibody
Product Synonym Names
EC=2.7.11.1; MGC21111
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human MINK1/2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
149,822 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (4736635..4801356). Location: 17p13.2
OMIM
609426
3D Structure
ModBase 3D Structure for Q8N4C8
Immunogen
Synthetic peptide selected from the C-terminal region of human MINK1/2 (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-MINK antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-MINK antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MINK antibody
IHC: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MINK antibody

1. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2. Dan, I., et al., FEBS Lett. 469(1):19-23 (2000).

Other Notes

Small volumes of anti-MINK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MINK. It may not necessarily be applicable to this product.

NCBI GI #
68161546
NCBI GeneID
50488
NCBI Accession #
NP_001020108.1
UniProt Primary Accession #
Q8N4C8
UniProt Secondary Accession #
Q5U8Z0; Q9P1X1; Q9P2R8; D3DTK3; D3DTK4
UniProt Related Accession #
Q8N4C8
GenBank Nucleotide #
NM_001024937.3
NCBI Official Full Name
misshapen-like kinase 1 isoform 4
NCBI Official Synonym Full Names
misshapen-like kinase 1
NCBI Official Symbol
MINK1
NCBI Official Synonym Symbols
B55; ZC3; MINK; YSK2; hMINK; MAP4K6; hMINKbeta
UniProt Protein Name
Misshapen-like kinase 1
UniProt Synonym Protein Names
GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
UniProt Gene Name
MINK1
UniProt Synonym Gene Names
B55; MAP4K6; MINK; YSK2; ZC3; MEK kinase kinase 6; MEKKK 6
UniProt Entry Name
MINK1_HUMAN
NCBI Protein Information
misshapen-like kinase 1; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/threonine protein kinase; mitogen-activated protein kinase kinase kinase kinase 6

NCBI Summary for MINK

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for MINK

MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: Golgi apparatus; postsynaptic membrane; axon; dendrite; cytoplasm; postsynaptic density; cell junction; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: regulation of cell-matrix adhesion; multicellular organismal development; protein amino acid autophosphorylation; dendrite morphogenesis; positive regulation of JNK cascade; negative thymic T cell selection; regulation of cell migration; protein amino acid phosphorylation; microvillus biogenesis; synaptic transmission; regulation of cell-cell adhesion; regulation of catalytic activity; actin cytoskeleton reorganization; JNK cascade; response to stress
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Research Articles on MINK

1. Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MINK antibody

 Products by Pathway  Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-MINK antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with MINK and Breast Neoplasms

Organs/Tissues associated with anti-MINK antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with MINK and Nerve
 Bone Antibodies  >1 publications with MINK and Bone
 Embryonic Tissue Antibodies  >1 publications with MINK and Embryonic Tissue
 Eye Antibodies  >1 publications with MINK and Eye
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