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ITPKB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648824

ITPKB regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ITPKB, Polyclonal Antibody
Full Product Name
ITPKB (Inositol-trisphosphate 3-kinase B, Inositol 1,4,5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B)
Product Gene Name
Product Synonym Names
Anti -ITPKB (Inositol-trisphosphate 3-kinase B, Inositol 1,4,5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B)
Immunogen Sequence
MAVYCYALNS LVIMNSANEM KSGGGPGPSG SETPPPPRRA VLSPGSVFSP GRGASFLFPP AESLSPEEPR SPGGWRSGRR RLNSSSGSGS GSSGSSVSSP SWAGRLRGDR QQVVAAGTLS PPGPEEAKRK LRILQRELQN VQVNQKVGMF EAHIQAQSSA IQAPRSPRLG RAHSPSPCPF RSSSQPPGRV LVQGARSEER RTKSWGEQCP ETSGTDSGRK GGPSLCSSQV KKGMPPLPGR AAPTGSEAQG PSAFVRMEKG IPASPRCGSP TAMEIDKRGS PTPGTRSCLA PSLGLFGASL TMATEVAARV TSTGPHRPQD LALTEPSGRA RELEDLQPPE ALVERQGQFL GSETSPAPER GGPRDGEPPG KMGKGYLPCG MPGSGEPEVG KRPEETTVSV QSAESSDALS WSRLPRALAS VGPEEARSGA PVGGGRWQLS DRVEGGSPTL GLLGGSPSAQ PGTGNVEAGI PSGRMLEPLP CWDAAKDLKE PQCPPGDRVG VQPGNSRVWQ GTMEKAGLAW TRGTGVQSEG TWESQRQDSD ALPSPELLPQ DQDKPFLRKA CSPSNIPAVI ITDMGTQEDG ALEETQGSPR GNLPLRKLSS SSASSTGFSS SYEDSEEDIS SDPERTLDPN SAFLHTLDQQ KPRV
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human ITPKB. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
102,376 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (226819391..226927028, complement). Location: 1q42.13
OMIM
147522
3D Structure
ModBase 3D Structure for P27987
Immunogen
Full length human ITPKB, aa1-644 (AAH15009.1).
Applications Tested/Suitable for anti-ITPKB antibody
Western Blot (WB)
Application Notes for anti-ITPKB antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-ITPKB antibody

ITPKB rabbit polyclonal antibody. Western Blot analysis of ITPKB expression in mouse liver.
Rabbit Anti-ITPKB Polyclonal Antibody – Cat# MBS648824

Western Blot (WB) of anti-ITPKB antibody

Western Blot analysis of ITPKB expression in transfected 293T cell line by ITPKB polyclonal antibody. Lane 1: ITPKB transfected lysate (67.4kD). Lane 2: Non-transfected lysate.
Rabbit Anti-ITPKB Polyclonal Antibody, Western Blot (WB) – Cat# MBS648824

Other Notes

Small volumes of anti-ITPKB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITPKB purchase

MBS648824 is an antibody targeting ITPKB. Also known as ITPKB (Inositol-trisphosphate 3-kinase B, Inositol 1,4,5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITPKB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
inositol-trisphosphate 3-kinase B
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase B
NCBI Official Symbol
ITPKB
NCBI Official Synonym Symbols
IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
UniProt Protein Name
Inositol-trisphosphate 3-kinase B
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase B
UniProt Gene Name
ITPKB
UniProt Synonym Gene Names
IP3 3-kinase B; IP3K B
UniProt Entry Name
IP3KB_HUMAN
NCBI Protein Information
inositol-trisphosphate 3-kinase B; IP3K B; IP3 3-kinase B; insP 3-kinase B; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B

NCBI Summary for ITPKB

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for ITPKB

Catalytic activity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulation: IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.

Subunit structure: Interacts with DMTN. Ref.9

Sequence similarities: Belongs to the inositol phosphokinase (IPK) family.

Sequence caution: The sequence CAA40491.1 differs from that shown. Reason: Erroneous initiation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITPKB antibody

 Reference Product  PubMed Publications
 IPMK antibody  >2 publications with ITPKB and IPMK

Diseases associated with anti-ITPKB antibody

Organs/Tissues associated with anti-ITPKB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ITPKB and Brain
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