Goat Anti-FOXE1 Polyclonal Antibody – Cat# MBS648837

(2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

FOXE1 Antibody – Goat Polyclonal

Name: FOXE1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648837
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648837

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FOXE1, Polyclonal Antibody

Full Product Name

FOXE1 (Forkhead Box Protein E1, Forkhead Box Protein E2, Forkhead-related Protein FKHL15, HFKH4, HNF-3/Fork Head-like Protein 5, HFKL5, Thyroid Transcription Factor 2, TTF-2, FKHL15, FOXE2, TITF2, TTF2)

Product Gene Name

anti-FOXE1 antibody

Product Synonym Names

Anti -FOXE1 (Forkhead Box Protein E1, Forkhead Box Protein E2, Forkhead-related Protein FKHL15, HFKH4, HNF-3/Fork Head-like Protein 5, HFKL5, Thyroid Transcription Factor 2, TTF-2, FKHL15, FOXE2, TITF2, TTF2)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human FOXE1.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

38,076 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (100615537..100618997). Location: 9q22

OMIM

241850

3D Structure

ModBase 3D Structure for O00358

Immunogen

Synthetic peptide corresponding to C-AYPGGIDRFVSAM, from human FOXE1, at C-terminal (NP_004464.2).

Product Categories/Family for anti-FOXE1 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-FOXE1 antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-FOXE1 antibody

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:32,000
Immunohistochemistry (Paraffin): 1-3ug/ml

Other Notes

Small volumes of anti-FOXE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXE1 purchase

MBS648837 is an antibody targeting FOXE1. Also known as FOXE1 (Forkhead Box Protein E1, Forkhead Box Protein E2, Forkhead-related Protein FKHL15, HFKH4, HNF-3/Fork Head-like Protein 5, HFKL5, Thyroid Transcription Factor 2, TTF-2, FKHL15, FOXE2, TITF2, TTF2). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXE1. It may not necessarily be applicable to this product.

NCBI GI #

21618325

NCBI GeneID

2304

NCBI Accession #

NP_004464.2

UniProt Primary Accession #

O00358

UniProt Secondary Accession #

O75765; Q5T109; Q99526

UniProt Related Accession #

O00358

GenBank Nucleotide #

NM_004473.3

NCBI Official Full Name

forkhead box protein E1

NCBI Official Synonym Full Names

forkhead box E1 (thyroid transcription factor 2)

NCBI Official Symbol

FOXE1

NCBI Official Synonym Symbols

TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15

UniProt Protein Name

Forkhead box protein E1

UniProt Synonym Protein Names

Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2

Protein Family

Forkhead box protein

UniProt Gene Name

FOXE1

UniProt Synonym Gene Names

FKHL15; FOXE2; TITF2; TTF2; HFKL5; TTF-2

UniProt Entry Name

FOXE1_HUMAN

NCBI Protein Information

forkhead box protein E1; forkhead box E2; forkhead box protein E2; HNF-3/fork head-like protein 5; thyroid transcription factor 2; forkhead-related protein FKHL15; forkhead, drosophila, homolog-like 15

UniProt Comments for FOXE1

Function: Probable transcription factor. Could be involved in thyroid gland organogenesis.

Subcellular location: Nucleus

Potential.

Tissue specificity: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.

Post-translational modification: Phosphorylated

By similarity.

Polymorphism: An alanine stretch that varies from 12 to 19 residues is present. This polymorphisms can be used as a marker to study the role of FOXE1 in other cases of thyroid dysgenesis, especially in familial cases.

Involvement in disease: Bamforth-Lazarus syndrome (BLS) [MIM:241850]: A disease characterized by thyroid agenesis, cleft palate and choanal atresia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7

Sequence similarities: Contains 1 fork-head DNA-binding domain.

Sequence caution: The sequence CAA64246.1 differs from that shown. Reason: Several conflicts.

Research Articles on FOXE1

1. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXE1 antibody

Reference Product	PubMed Publications
PAX8 antibody	>43 publications with FOXE1 and PAX8
NKX2-1 antibody	>14 publications with FOXE1 and NKX2-1
TPO antibody	>12 publications with FOXE1 and TPO
TSHR antibody	>10 publications with FOXE1 and TSHR
GLI2 antibody	>7 publications with FOXE1 and GLI2
TBX10 antibody	>2 publications with FOXE1 and TBX10
HEMGN antibody	>1 publications with FOXE1 and HEMGN
C9orf156 antibody	>1 publications with FOXE1 and C9orf156

Diseases associated with anti-FOXE1 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>5 publications with FOXE1 and Adenocarcinoma
Bamforth syndrome Antibodies	>4 publications with FOXE1 and Bamforth syndrome
Breast Neoplasms Antibodies	>3 publications with FOXE1 and Breast Neoplasms
Inflammation Antibodies	>3 publications with FOXE1 and Inflammation
Cell Transformation, Neoplastic Antibodies	>2 publications with FOXE1 and Cell Transformation, Neoplastic
Cysts Antibodies	>2 publications with FOXE1 and Cysts
Hyperplasia Antibodies	>2 publications with FOXE1 and Hyperplasia
Necrosis Antibodies	>1 publications with FOXE1 and Necrosis
Brain Diseases Antibodies	>1 publications with FOXE1 and Brain Diseases
Disorders of Sex Development Antibodies	>1 publications with FOXE1 and Disorders of Sex Development

Organs/Tissues associated with anti-FOXE1 antibody

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>97 publications with FOXE1 and Thyroid
Brain Antibodies	>8 publications with FOXE1 and Brain
Skin Antibodies	>7 publications with FOXE1 and Skin
Testis Antibodies	>2 publications with FOXE1 and Testis