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INHBE Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648860

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
INHBE, Monoclonal Antibody
Full Product Name
INHBE (Inhibin beta E Chain, Activin beta-E Chain, MGC4638)
Product Gene Name
anti-INHBE antibody
Product Synonym Names
Anti -INHBE (Inhibin beta E Chain, Activin beta-E Chain, MGC4638)
Immunogen Sequence
GTGSVCPSCG GSKLAPQAER ALVLELAKQQ ILDGLHLTSR PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD STSAYSSLLT FHLSTPRSHH LYHARLWLHV LPTLPGTLCL RIFRWGPRRR RQGSRTLLAE HHITNLGWHT LTLPSSGLRG EKSGVLKLQL DCRPLEGNST VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC EPATPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
4B5
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Concentration
0.5mg/mL (lot specific)
Specificity
Recognizes human INHBE.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 12; NC_000012.11 (57849096..57851791). Location: 12q13.3
OMIM
612031
3D Structure
ModBase 3D Structure for P58166
Immunogen
Full length recombinant corresponding to aa21-351 from human INHBE (AAH05161) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-INHBE antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-INHBE antibody
ELISA (EIA)
Application Notes for anti-INHBE antibody
Suitable for use in ELISA. Optimal dilutions should be determined by the researcher. Other applications not tested.

Other Notes

Small volumes of anti-INHBE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INHBE purchase

MBS648860 is an antibody targeting INHBE. Also known as INHBE (Inhibin beta E Chain, Activin beta-E Chain, MGC4638). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for INHBE. It may not necessarily be applicable to this product.

NCBI GI #
13899338
NCBI GeneID
83729
NCBI Accession #
NP_113667.1
UniProt Primary Accession #
P58166
UniProt Related Accession #
P58166
GenBank Nucleotide #
NM_031479.3
NCBI Official Full Name
inhibin beta E chain
NCBI Official Synonym Full Names
inhibin, beta E
NCBI Official Symbol
INHBE
UniProt Protein Name
Inhibin beta E chain
UniProt Synonym Protein Names
Activin beta-E chain
Protein Family
Inhibin
UniProt Gene Name
INHBE
UniProt Entry Name
INHBE_HUMAN
NCBI Protein Information
inhibin beta E chain; activin beta E; activin beta-E chain

NCBI Summary for INHBE

INHBE is a member of the activin beta family (see INHBA; MIM 147290) that plays a role in pancreatic exocrine cell growth and proliferation (Hashimoto et al., 2006 [PubMed 16426570]).[supplied by OMIM, May 2008]

UniProt Comments for INHBE

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the TGF-beta family.
Show more

Research Articles on INHBE

1. differential expression pattern of the betaC- and betaE-subunits in normal human endometrial tissue suggests that they function in endometrial maturation and blastocyst implantation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-INHBE antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Biosynthesis Pathway antibodies  Peptide Hormone Biosynthesis Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Organs/Tissues associated with anti-INHBE antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with INHBE and Embryonic Tissue
 Liver Antibodies  >3 publications with INHBE and Liver
 Cervix Antibodies  >1 publications with INHBE and Cervix
 Bone Marrow Antibodies  >1 publications with INHBE and Bone Marrow
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