GALNTL5 Antibody – Rabbit Polyclonal

Function: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor

By similarity.

Cofactor: Manganese

By similarity.Calcium

By similarity.

Pathway: Protein modification; protein glycosylation.

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein

By similarity.

Tissue specificity: Expressed in testis.

Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding

By similarity.

Sequence similarities: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Caution: In contrast to other members of the family, it lacks the C-terminal ricin B-type lectin domain that contributes to the glycopeptide specificity, and lacks the conserved His residue in position 341. The precise function of the enzyme is therefore unsure.

Sequence caution: The sequence AAH49554.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.