Rabbit Anti-SENP5 Polyclonal Antibody – Cat# MBS648936

SENP5 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SENP5 antibody detected the SENP5 protein (arrow).

SENP5 Antibody – Rabbit Polyclonal

Name: SENP5 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648936
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648936

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SENP5, Polyclonal Antibody

Full Product Name

SENP5, CT (SENP5, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5)

Product Gene Name

anti-SENP5 antibody

Product Synonym Names

Anti -SENP5, CT (SENP5, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

86,693 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (196594727..196661585). Location: 3q29

OMIM

612845

3D Structure

ModBase 3D Structure for Q96HI0

Immunogen

SENP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-747 amino acids from the C-terminal region of human SENP5.

Product Categories/Family for anti-SENP5 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)

Applications Tested/Suitable for anti-SENP5 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SENP5 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SENP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SENP5 purchase

MBS648936 is an antibody targeting SENP5. Also known as SENP5, CT (SENP5, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP5. It may not necessarily be applicable to this product.

NCBI GI #

159032029

NCBI GeneID

205564

NCBI Accession #

NP_689912.2

UniProt Primary Accession #

Q96HI0

UniProt Secondary Accession #

Q96SA5

UniProt Related Accession #

Q96HI0

GenBank Nucleotide #

NM_152699.4

NCBI Official Full Name

sentrin-specific protease 5

NCBI Official Synonym Full Names

SUMO1/sentrin specific peptidase 5

NCBI Official Symbol

SENP5

UniProt Protein Name

Sentrin-specific protease 5

UniProt Synonym Protein Names

Sentrin/SUMO-specific protease SENP5

Protein Family

Sentrin-specific protease

UniProt Gene Name

SENP5

UniProt Entry Name

SENP5_HUMAN

NCBI Protein Information

sentrin-specific protease 5; SUMO1/sentrin specific protease 5; sentrin/SUMO-specific protease SENP5

UniProt Comments for SENP5

Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Ref.5 Ref.6

Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Subcellular location: Nucleus › nucleolus Ref.5 Ref.6.

Sequence similarities: Belongs to the peptidase C48 family.

Sequence caution: The sequence AAK69630.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on SENP5

1. altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SENP5 antibody

Reference Product	PubMed Publications
SUMO2 antibody	>3 publications with SENP5 and SUMO2
SUMO3 antibody	>3 publications with SENP5 and SUMO3
SUMO1 antibody	>3 publications with SENP5 and SUMO1
RANGAP1 antibody	>2 publications with SENP5 and RANGAP1

Pathways associated with anti-SENP5 antibody

Products by Pathway	Pathway Diagram
Processing And Activation Of SUMO Pathway antibodies	Processing And Activation Of SUMO Pathway Diagram
Proteolytic Processing Of SUMO Pathway antibodies	Proteolytic Processing Of SUMO Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram

Diseases associated with anti-SENP5 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with SENP5 and Neoplasms

Organs/Tissues associated with anti-SENP5 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>2 publications with SENP5 and Heart
Prostate Antibodies	>1 publications with SENP5 and Prostate
Embryonic Tissue Antibodies	>1 publications with SENP5 and Embryonic Tissue
Mouth Antibodies	>1 publications with SENP5 and Mouth