• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

WHSC1L1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648938

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WHSC1L1, Polyclonal Antibody
Full Product Name
WHSC1L1, NT (WHSC1L1, NSD3, Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1)
Product Gene Name
anti-WHSC1L1 antibody
Product Synonym Names
Anti -WHSC1L1, NT (WHSC1L1, NSD3, Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
161,613 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (38127217..38239872, complement). Location: 8p11.2
OMIM
607083
3D Structure
ModBase 3D Structure for Q9BZ95
Immunogen
WHSC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-225 amino acids from the N-terminal region of human WHSC1L1.

Product Categories/Family for anti-WHSC1L1 antibody

Antibodies; Abs to Enzymes; Methyltransferase
Applications Tested/Suitable for anti-WHSC1L1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-WHSC1L1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100

Western Blot (WB) of anti-WHSC1L1 antibody

Western blot analysis of WHSC1L1 (arrow) using rabbit polyclonal WHSC1L1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the WHSC1L1 gene.
Rabbit Anti-WHSC1L1 Polyclonal Antibody – Cat# MBS648938

Other Notes

Small volumes of anti-WHSC1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WHSC1L1 purchase

MBS648938 is an antibody targeting WHSC1L1. Also known as WHSC1L1, NT (WHSC1L1, NSD3, Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WHSC1L1. It may not necessarily be applicable to this product.

NCBI GI #
219841942
NCBI GeneID
54904
NCBI Accession #
AAI43511.1
UniProt Primary Accession #
Q9BZ95
UniProt Secondary Accession #
Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9H2M8; Q9H9W9; Q9NXA6; D3DSX1
UniProt Related Accession #
Q9BZ95
NCBI Official Full Name
WHSC1L1 protein
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Symbol
WHSC1L1
NCBI Official Synonym Symbols
NSD3; pp14328
UniProt Protein Name
Histone-lysine N-methyltransferase NSD3
UniProt Synonym Protein Names
Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
WHSC1L1
UniProt Synonym Gene Names
NSD3; WHSC1-like protein 1
UniProt Entry Name
NSD3_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase NSD3; protein whistle; WHSC1-like protein 1; nuclear SET domain-containing protein 3; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine

UniProt Comments for WHSC1L1

Function: Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Ref.9

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.9

Subunit structure: Interacts with BRD4. Ref.11

Subcellular location: Nucleus

By similarity. Chromosome

By similarity.

Tissue specificity: Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. Ref.2

Involvement in disease: Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC. Ref.8A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

Sequence similarities: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 4 PHD-type zinc fingers.Contains 1 post-SET domain.Contains 2 PWWP domains.Contains 1 SET domain.

Sequence caution: The sequence AAG44637.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAI07735.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAA91110.1 differs from that shown. Reason: Erroneous initiation.
Show more

Research Articles on WHSC1L1

1. Data indicate that siRNA attenuated the expression levels of CCNG1 and NEK7, implying that WHSC1L1 appears to activate the expression of CCNG1 and NEK7 in cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WHSC1L1 antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-WHSC1L1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with WHSC1L1 and Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >3 publications with WHSC1L1 and Leukemia, Myeloid, Acute
 Cell Transformation, Neoplastic Antibodies  >2 publications with WHSC1L1 and Cell Transformation, Neoplastic
 Neoplasm Invasiveness Antibodies  >1 publications with WHSC1L1 and Neoplasm Invasiveness
 Neurobehavioral Manifestations Antibodies  >1 publications with WHSC1L1 and Neurobehavioral Manifestations
 Mental Disorders Antibodies  >1 publications with WHSC1L1 and Mental Disorders
 Nervous System Diseases Antibodies  >1 publications with WHSC1L1 and Nervous System Diseases
 Death Antibodies  >1 publications with WHSC1L1 and Death
 Liver Neoplasms Antibodies  >1 publications with WHSC1L1 and Liver Neoplasms
 Learning Disorders Antibodies  >1 publications with WHSC1L1 and Learning Disorders

Organs/Tissues associated with anti-WHSC1L1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with WHSC1L1 and Lung
 Bone Marrow Antibodies  >2 publications with WHSC1L1 and Bone Marrow
 Bone Antibodies  >2 publications with WHSC1L1 and Bone
 Blood Antibodies  >2 publications with WHSC1L1 and Blood
 Liver Antibodies  >1 publications with WHSC1L1 and Liver
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000