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FNIP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648958

May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions By similarity. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of… More details

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Product Overview

Online Datasheet in PDF
Product Name
FNIP2, Polyclonal Antibody
Full Product Name
FNIP2, NT (Folliculin-interacting Protein 2, FNIP1-like Protein, O6-methylguanine-induced Apoptosis 1 Protein, FNIPL, KIAA1450, MAPO1)
Product Gene Name
anti-FNIP2 antibody
Product Synonym Names
Anti -FNIP2, NT (Folliculin-interacting Protein 2, FNIP1-like Protein, O6-methylguanine-induced Apoptosis 1 Protein, FNIPL, KIAA1450, MAPO1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human FNIP2. Species sequence homology: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
122,115 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (159690182..159829202). Location: 4q32.1
OMIM
612768
3D Structure
ModBase 3D Structure for Q9P278
Immunogen
Synthetic peptide corresponding to 18aa from human FNIP2 at N-terminus.

Product Categories/Family for anti-FNIP2 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-FNIP2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FNIP2 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-FNIP2 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-FNIP2 Polyclonal Antibody – Cat# MBS648958

Western Blot (WB) of anti-FNIP2 antibody

Western blot analysis of FNIP2 in mouse skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2ug/ml.
Rabbit Anti-FNIP2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS648958

Other Notes

Small volumes of anti-FNIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FNIP2 purchase

MBS648958 is an antibody targeting FNIP2. Also known as FNIP2, NT (Folliculin-interacting Protein 2, FNIP1-like Protein, O6-methylguanine-induced Apoptosis 1 Protein, FNIPL, KIAA1450, MAPO1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FNIP2. It may not necessarily be applicable to this product.

NCBI GI #
154689769
NCBI GeneID
57600
NCBI Accession #
NP_065891.1
UniProt Primary Accession #
Q9P278
UniProt Secondary Accession #
Q05DC3; Q96I31; Q9H994
UniProt Related Accession #
Q9P278
GenBank Nucleotide #
NM_020840.1
NCBI Official Full Name
folliculin-interacting protein 2
NCBI Official Synonym Full Names
folliculin interacting protein 2
NCBI Official Symbol
FNIP2
NCBI Official Synonym Symbols
FNIPL; MAPO1
UniProt Protein Name
Folliculin-interacting protein 2
UniProt Synonym Protein Names
FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein
Protein Family
Folliculin-interacting protein
UniProt Gene Name
FNIP2
UniProt Synonym Gene Names
FNIPL; KIAA1450; MAPO1
UniProt Entry Name
FNIP2_HUMAN
NCBI Protein Information
folliculin-interacting protein 2; FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein

UniProt Comments for FNIP2

Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions

By similarity. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Ref.4 Ref.5

Subunit structure: Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Ref.4 Ref.5

Subcellular location: Cytoplasm. Note: Colocalizes with FLCN in the cytoplasm. Ref.4 Ref.5 Ref.6

Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney. Ref.4 Ref.5

Post-translational modification: Phosphorylated by AMPK. Ref.5

Miscellaneous: Elevated expression levels in histologic variants of renal tumors.

Sequence similarities: Belongs to the FNIP family.

Sequence caution: The sequence AAH07861.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAH16638.1 differs from that shown. Reason: Potential poly-A sequence.The sequence BAA95974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAB14338.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on FNIP2

1. this study obtained evidence to show that stabilization of MAPO1 is regulated through its specific interaction with folliculin and AMPK.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FNIP2 antibody

 Reference Product  PubMed Publications
 FLCN antibody  >9 publications with FNIP2 and FLCN

Diseases associated with anti-FNIP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with FNIP2 and Neoplasms
 Kidney Neoplasms Antibodies  >3 publications with FNIP2 and Kidney Neoplasms
 Kidney Diseases Antibodies  >3 publications with FNIP2 and Kidney Diseases

Organs/Tissues associated with anti-FNIP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with FNIP2 and Kidney
 Lung Antibodies  >2 publications with FNIP2 and Lung
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