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Cystinosin (CTNS) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648970

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cystinosin (Ctns), Monoclonal Antibody
Full Product Name
Cystinosin (CTNS)
Product Gene Name
Product Synonym Names
Anti -Cystinosin (CTNS)
Immunogen Sequence
MIRNWLTIFI LFPLKLVEKC ESSVSLTVPP VVKLENGSST NVSLTLRPPL NATLVITFEI TFRSKNITIL ELPDEVVVPP GVTNSSFQVT SQNVGQLTVY
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
5G6
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CTNS. Species Crossreactivity: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,203 Da
Chromosome Location
Chromosome: 11; NC_000077.6 (73183133..73199019, complement). Location: 11 B4; 11
3D Structure
ModBase 3D Structure for P57757
Immunogen
Partial recombinant corresponding to aa1-100 from human CTNS (NP_004928) with GST tag. MW of the GST tag alone is 26kD.
Applications Tested/Suitable for anti-Ctns antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Ctns antibody
Suitable for use in ELISA and Western Blot.

Testing Data of anti-Ctns antibody

Detection limit is ~0.3ng/ml using MBS648970 as a capture antibody.
Mouse Anti-CTNS Monoclonal Antibody – Cat# MBS648970

Western Blot (WB) of anti-Ctns antibody

Western Blot analysis of CTNS expression in human liver using MBS648970.
Mouse Anti-CTNS Monoclonal Antibody, Western Blot (WB) – Cat# MBS648970

Western Blot (WB) of anti-Ctns antibody

Western Blot analysis of CTNS expression in HepG2 using MBS648970 .
Mouse Anti-CTNS Monoclonal Antibody, Western Blot (WB) – Cat# MBS648970

Western Blot (WB) of anti-Ctns antibody

Western Blot analysis of CTNS expression in Raw 264.7 using MBS648970.
Mouse Anti-CTNS Monoclonal Antibody, Western Blot (WB) – Cat# MBS648970

Western Blot (WB) of anti-Ctns antibody

Western Blot detection against immunogen using MBS648970 (36.74kD).
Mouse Anti-CTNS Monoclonal Antibody, Western Blot (WB) – Cat# MBS648970

Western Blot (WB) of anti-Ctns antibody

Western Blot analysis of CTNS expression in PC-12 using MBS648970.
Mouse Anti-CTNS Monoclonal Antibody, Western Blot (WB) – Cat# MBS648970

Other Notes

Small volumes of anti-Ctns antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctns purchase

MBS648970 is an antibody targeting Ctns. Also known as Cystinosin (CTNS). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Ctns. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cystinosin
NCBI Official Synonym Full Names
cystinosis, nephropathic
NCBI Official Symbol
Ctns
NCBI Official Synonym Symbols
AI195360; AW049661
UniProt Protein Name
Cystinosin
Protein Family
UniProt Gene Name
Ctns
UniProt Entry Name
CTNS_MOUSE
NCBI Protein Information
cystinosin

UniProt Comments for Ctns

Function: Thought to transport cystine out of lysosomes.

Subcellular location: Lysosome membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the cystinosin family.Contains 2 PQ-loop domains.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ctns antibody

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