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AGBL5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648973

AGBL5 has a function in the processing of cytosolic proteins such as alpha tubulin, which is known to be modified by the removal of a C terminal tyrosine. It is expressed in the brain. There are three named isoforms. More details

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Product Overview

Online Datasheet in PDF
Product Name
AGBL5, Polyclonal Antibody
Full Product Name
AGBL5, NT (AGBL5, CCP5, Cytosolic carboxypeptidase-like protein 5, ATP/GTP-binding protein-like 5)
Product Gene Name
anti-AGBL5 antibody
Product Synonym Names
Anti -AGBL5, NT (AGBL5, CCP5, Cytosolic carboxypeptidase-like protein 5, ATP/GTP-binding protein-like 5)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
97,534 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (27274291..27293490). Location: 2p23.3
3D Structure
ModBase 3D Structure for Q8NDL9
Immunogen
AGBL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human AGBL5.

Product Categories/Family for anti-AGBL5 antibody

Antibodies; Abs to Enzymes; Carboxypeptidase
Applications Tested/Suitable for anti-AGBL5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AGBL5 antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-AGBL5 antibody

AGBL5 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the AGBL5 antibody detected the AGBL5 protein (arrow).
Rabbit Anti-AGBL5 Polyclonal Antibody – Cat# MBS648973

Immunohistochemistry (IHC) of anti-AGBL5 antibody

AGBL5 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AGBL5 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-AGBL5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648973

Immunofluorescence (IF) of anti-AGBL5 antibody

Confocal immunofluorescent analysis of AGBL5 Antibody (N-term) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-AGBL5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS648973

Other Notes

Small volumes of anti-AGBL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGBL5 purchase

MBS648973 is an antibody targeting AGBL5. Also known as AGBL5, NT (AGBL5, CCP5, Cytosolic carboxypeptidase-like protein 5, ATP/GTP-binding protein-like 5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGBL5. It may not necessarily be applicable to this product.

NCBI GI #
112180308
NCBI GeneID
60509
NCBI Accession #
AAH07415.2
UniProt Primary Accession #
Q8NDL9
UniProt Secondary Accession #
Q53SW0; Q53SZ0; Q96IK8; Q9H6V0; Q9H8P8; A2VDI7; B7WPG9; B7Z7I7; D6W548
UniProt Related Accession #
Q8NDL9
NCBI Official Full Name
AGBL5 protein
NCBI Official Synonym Full Names
ATP/GTP binding protein-like 5
NCBI Official Symbol
AGBL5
UniProt Protein Name
Cytosolic carboxypeptidase-like protein 5
UniProt Synonym Protein Names
ATP/GTP-binding protein-like 5
Protein Family
Cytosolic carboxypeptidase-like protein
UniProt Gene Name
AGBL5
UniProt Synonym Gene Names
CCP5
UniProt Entry Name
CBPC5_HUMAN
NCBI Protein Information
cytosolic carboxypeptidase-like protein 5; ATP/GTP-binding protein-like 5

UniProt Comments for AGBL5

Function: Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6

By similarity.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subcellular location: Cytoplasm › cytosol

By similarity. Nucleus

By similarity. Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed

By similarity.

Tissue specificity: Expressed in brain.

Sequence similarities: Belongs to the peptidase M14 family.

Sequence caution: The sequence AAX93164.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAY14655.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on AGBL5

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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