Mouse Anti-FAIM2 Monoclonal Antibody – Cat# MBS649036

Western Blot detection against Immunogen (60.87kD).

Mouse Anti-FAIM2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS649036

FAIM2 Antibody – Mouse Monoclonal

Name: FAIM2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649036
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649036

MBS649036 is an antibody targeting Faim2. Also known as FAIM2 (KIAA0950, LFG, LFG2, NMP35, TMBIM2, Protein Lifeguard 2, Fas Apoptotic Inhibitory Molecule 2, Neural Membrane Protein 35, Transmembrane BAX Inhibitor Motif-containing Protein 2). Reactive in… More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FAIM2, Monoclonal Antibody

Full Product Name

FAIM2 (KIAA0950, LFG, LFG2, NMP35, TMBIM2, Protein Lifeguard 2, Fas Apoptotic Inhibitory Molecule 2, Neural Membrane Protein 35, Transmembrane BAX Inhibitor Motif-containing Protein 2)

Product Gene Name

anti-Faim2 antibody

Product Synonym Names

Anti -FAIM2 (KIAA0950, LFG, LFG2, NMP35, TMBIM2, Protein Lifeguard 2, Fas Apoptotic Inhibitory Molecule 2, Neural Membrane Protein 35, Transmembrane BAX Inhibitor Motif-containing Protein 2)

Immunogen Sequence

MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV PWLHA

Clonality

Monoclonal

Isotype

IgG2a,k

Clone Number

2C2

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human FAIM2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

35,258 Da

Chromosome Location

Chromosome: 15; NC_000081.6 (99497005..99528017, complement). Location: 15; 15 F3

3D Structure

ModBase 3D Structure for Q8K097

Immunogen

Full-length recombinant corresponding to aa1-317 from FAIM2 (AAH00051) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-Faim2 antibody

Antibodies; Abs to Transmembrane Proteins

Applications Tested/Suitable for anti-Faim2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Faim2 antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-Faim2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Faim2. It may not necessarily be applicable to this product.

NCBI GI #

21619018

NCBI GeneID

72393

NCBI Accession #

AAH32278.1

UniProt Primary Accession #

Q8K097

UniProt Secondary Accession #

Q3TY22; Q8K1F6; Q9D6K4

UniProt Related Accession #

Q8K097

NCBI Official Full Name

Faim2 protein

NCBI Official Synonym Full Names

Fas apoptotic inhibitory molecule 2

NCBI Official Symbol

Faim2

NCBI Official Synonym Symbols

Lfg; Lfg2; NMP25; Nmp35; 2900002L20Rik

UniProt Protein Name

Protein lifeguard 2

UniProt Synonym Protein Names

Fas apoptotic inhibitory molecule 2; Neural membrane protein 35

Protein Family

Protein lifeguard

UniProt Gene Name

Faim2

UniProt Synonym Gene Names

Kiaa0950; Lfg; Lfg2; Nmp35

UniProt Entry Name

LFG2_MOUSE

NCBI Protein Information

protein lifeguard 2; neural membrane protein 35

UniProt Comments for Faim2

Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Ref.5 Ref.8 Ref.9

Subunit structure: Interacts with FAS/TNFRSF6 and BAX

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Membrane raft. Cell junction › synapse › postsynaptic cell membrane

By similarity Ref.5.

Tissue specificity: Brain. Highly expressed in cerebellum, also found in cortex, olfactory bulb, and hippocampus. Ref.5 Ref.9

Disruption phenotype: Mice show reduced cerebellar size and internal granular layer (IGL) thickness in early developmental stages, delayed Purkinje Cell (PC) development, with an abnormal morphology and reduced cellular density, increased caspase-8 and caspase-3 activity in PCs and higher sensitivity to Fas-mediated apoptosis. Ref.9

Sequence similarities: Belongs to the BI1 family. LFG subfamily.

Sequence caution: The sequence BAC98056.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on Faim2

1. Expression of Faim2 is triggered, at least in part, by Fas-receptor activation and subsequent ERK signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Faim2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with Faim2 and Neoplasms
Disease Models, Animal Antibodies	>3 publications with Faim2 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>3 publications with Faim2 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>2 publications with Faim2 and Breast Neoplasms
Brain Diseases Antibodies	>2 publications with Faim2 and Brain Diseases
Necrosis Antibodies	>1 publications with Faim2 and Necrosis
Arteriosclerosis Antibodies	>1 publications with Faim2 and Arteriosclerosis
Atherosclerosis Antibodies	>1 publications with Faim2 and Atherosclerosis

Organs/Tissues associated with anti-Faim2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>11 publications with Faim2 and Brain
Eye Antibodies	>1 publications with Faim2 and Eye