Rabbit Anti-PTPN23 Polyclonal Antibody – Cat# MBS649064

PTPN23 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PTPN23 antibody detected the PTPN23 protein (arrow).

PTPN23 Antibody – Rabbit Polyclonal

Name: PTPN23 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649064
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649064

MBS649064 is an antibody targeting PTPN23. Also known as PTPN23, CT (PTPN23, KIAA1471, Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, Protein tyrosine phosphatase TD14). Reactive in Human. Host: Rabbit.… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTPN23, Polyclonal Antibody

Full Product Name

PTPN23, CT (PTPN23, KIAA1471, Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, Protein tyrosine phosphatase TD14)

Product Gene Name

anti-PTPN23 antibody

Product Synonym Names

Anti -PTPN23, CT (PTPN23, KIAA1471, Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, Protein tyrosine phosphatase TD14)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

178,974 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (47422383..47454931). Location: 3p21.3

OMIM

606584

3D Structure

ModBase 3D Structure for Q9H3S7

Immunogen

PTPN23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1180-1209 amino acids from the C-terminal region of human PTPN23.

Product Categories/Family for anti-PTPN23 antibody

Antibodies; Abs to Enzymes; Phosphatase

Applications Tested/Suitable for anti-PTPN23 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-PTPN23 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-PTPN23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN23. It may not necessarily be applicable to this product.

NCBI GI #

39644964

NCBI GeneID

25930

NCBI Accession #

AAH27711.2

UniProt Primary Accession #

Q9H3S7

UniProt Secondary Accession #

Q7KZF8; Q8N6Z5; Q9BSR5; Q9P257; Q9UG03; Q9UMZ4; A8K0D7

UniProt Related Accession #

Q9H3S7

NCBI Official Full Name

PTPN23 protein, partial

NCBI Official Synonym Full Names

protein tyrosine phosphatase, non-receptor type 23

NCBI Official Symbol

PTPN23

NCBI Official Synonym Symbols

HDPTP; HD-PTP; PTP-TD14

UniProt Protein Name

Tyrosine-protein phosphatase non-receptor type 23

UniProt Synonym Protein Names

His domain-containing protein tyrosine phosphatase; HD-PTP; Protein tyrosine phosphatase TD14

Protein Family

Tyrosine-protein phosphatase non-receptor

UniProt Gene Name

PTPN23

UniProt Synonym Gene Names

KIAA1471; HD-PTP; PTP-TD14

UniProt Entry Name

PTN23_HUMAN

NCBI Protein Information

tyrosine-protein phosphatase non-receptor type 23; protein tyrosine phosphatase TD14; His-domain protein tyrosine phosphatase; his domain-containing protein tyrosine phosphatase

UniProt Comments for PTPN23

Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. Ref.12 Ref.14 Ref.18

Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure: Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B. Ref.12 Ref.15 Ref.18

Subcellular location: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm › cytoskeleton › cilium basal body. Early endosome Ref.1 Ref.12 Ref.14 Ref.15.

Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 BRO1 domain.Contains 2 TPR repeats.Contains 1 tyrosine-protein phosphatase domain.

Sequence caution: The sequence BAA95995.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on PTPN23

1. The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR) and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN23 antibody

Reference Product	PubMed Publications
SRC antibody	>4 publications with PTPN23 and SRC
PDCD6IP antibody	>3 publications with PTPN23 and PDCD6IP
CHMP4B antibody	>3 publications with PTPN23 and CHMP4B
PTK2 antibody	>2 publications with PTPN23 and PTK2
SH3GL2 antibody	>1 publications with PTPN23 and SH3GL2
TSG101 antibody	>1 publications with PTPN23 and TSG101
GRB2 antibody	>1 publications with PTPN23 and GRB2
GRAP2 antibody	>1 publications with PTPN23 and GRAP2

Diseases associated with anti-PTPN23 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with PTPN23 and Brain Diseases
Urinary Bladder Neoplasms Antibodies	>1 publications with PTPN23 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-PTPN23 antibody

Organ/Tissue Name	Pubmed Publications
Bladder Antibodies	>2 publications with PTPN23 and Bladder
Heart Antibodies	>2 publications with PTPN23 and Heart
Embryonic Tissue Antibodies	>2 publications with PTPN23 and Embryonic Tissue
Vascular Antibodies	>2 publications with PTPN23 and Vascular
Brain Antibodies	>2 publications with PTPN23 and Brain
Mammary Gland Antibodies	>1 publications with PTPN23 and Mammary Gland
Blood Antibodies	>1 publications with PTPN23 and Blood
Placenta Antibodies	>1 publications with PTPN23 and Placenta
Lung Antibodies	>1 publications with PTPN23 and Lung
Intestine Antibodies	>1 publications with PTPN23 and Intestine