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Nucleoside Diphosphate Kinase C (NDPKC) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6490772

MBS6490772 is an antibody targeting NDPKC. Also known as Nucleoside Diphosphate Kinase C (NDPKC, NDPK-C, c371H6.2, DR-nm23, KIAA0516, Nucleoside Diphosphate Kinase 3, NDP Kinase 3, NDK 3, NDK3, NME3, NM23H3, nm23-H3) (APC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nucleoside Diphosphate Kinase C (NDPKC), Polyclonal Antibody
Full Product Name
Nucleoside Diphosphate Kinase C (NDPKC, NDPK-C, c371H6.2, DR-nm23, KIAA0516, Nucleoside Diphosphate Kinase 3, NDP Kinase 3, NDK 3, NDK3, NME3, NM23H3, nm23-H3) (APC)
Product Gene Name
anti-NDPKC antibody
Product Synonym Names
Non-metastatic Cells 3; Protein Expressed in; EC=2.7.4.6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human NME3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19.1 kDa (169aa), confirmed by MALDI-TOF
OMIM
601817
3D Structure
ModBase 3D Structure for Q13232
Immunogen
Synthetic peptide selected from the center region of human NME3 (KLH).
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-NDPKC antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-NDPKC antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-NDPKC antibody
IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NDPKC antibody

Western blot analysis of anti-NME3 Pab in CEM cell line tissue lysate (35ug/lane).NME3(arrow) was detected using the purified Pab.
Rabbit Anti-NDPKC Polyclonal Antibody – Cat# MBS6490772

Immunohistochemistry (IHC) of anti-NDPKC antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-NDPKC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6490772

Product References and Citations for anti-NDPKC antibody

1. Negroni, A., et al., Cell Death Differ. 7(9):843-850 (2000). 2. Martinez, R., et al., Cancer Res. 57(6):1180-1187 (1997). 3. Venturelli, D., et al., Proc. Natl. Acad. Sci. USA 92(16):7435-7439 (1995).

Other Notes

Small volumes of anti-NDPKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NDPKC. It may not necessarily be applicable to this product.

NCBI GI #
37693993
NCBI GeneID
4832
NCBI Accession #
NP_002504
UniProt Primary Accession #
Q13232
UniProt Secondary Accession #
Q9BWH4
UniProt Related Accession #
Q13232
GenBank Nucleotide #
NM_002513.2
NCBI Official Full Name
nucleoside diphosphate kinase 3
NCBI Official Synonym Full Names
NME/NM23 nucleoside diphosphate kinase 3
NCBI Official Symbol
NME3
NCBI Official Synonym Symbols
NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2
UniProt Protein Name
Nucleoside diphosphate kinase 3
UniProt Synonym Protein Names
DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3
Protein Family
Nucleoside diphosphate kinase
UniProt Gene Name
NME3
UniProt Synonym Gene Names
NDK 3; NDP kinase 3; NDPKC
UniProt Entry Name
NDK3_HUMAN
NCBI Protein Information
nucleoside diphosphate kinase 3

UniProt Comments for NDPKC

NME3: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Belongs to the NDK family.

Protein type: Kinase, other; Kinase, nucleoside diphosphate; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Apoptosis; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Other group; NDK family

Chromosomal Location of Human Ortholog: 16q13.3

Cellular Component: mitochondrion; cytosol

Molecular Function: metal ion binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; regulation of apoptosis; CTP biosynthetic process; apoptosis; pyrimidine nucleotide metabolic process; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process
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Research Articles on NDPKC

1. Thus Tip60 interacts with RNR and NME3 to provide site-specific synthesis of dNTP for facilitating DNA repair in serum-deprived cells which contain low levels of dNTPs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NDPKC antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-NDPKC antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >3 publications with NDPKC and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with NDPKC and Breast Neoplasms
 Seizures Antibodies  >1 publications with NDPKC and Seizures
 Disease Models, Animal Antibodies  >1 publications with NDPKC and Disease Models, Animal

Organs/Tissues associated with anti-NDPKC antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with NDPKC and Bone
 Intestine Antibodies  >2 publications with NDPKC and Intestine
 Blood Antibodies  >2 publications with NDPKC and Blood
 Embryonic Tissue Antibodies  >2 publications with NDPKC and Embryonic Tissue
 Ovary Antibodies  >1 publications with NDPKC and Ovary
 Lymph Antibodies  >1 publications with NDPKC and Lymph
 Lung Antibodies  >1 publications with NDPKC and Lung
 Muscle Antibodies  >1 publications with NDPKC and Muscle
 Pancreas Antibodies  >1 publications with NDPKC and Pancreas
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