YKT6 Antibody – Mouse Monoclonal

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]

Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Ref.1 Ref.7

Subunit structure: Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5

By similarity.

Subcellular location: Cytoplasm › cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note: Probably cycles through vesicles between Golgi and endosomes. Ref.7 Ref.8

Domain: The longin domain regulates palmitoylation and membrane targeting.

Post-translational modification: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting. Ref.6 Ref.8Farnesylation is required for Golgi targeting.

Sequence similarities: Belongs to the synaptobrevin family.Contains 1 longin domain.Contains 1 v-SNARE coiled-coil homology domain.