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OASL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6490935

MBS6490935 is an antibody targeting OASL. Also known as OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14) (PE). Reactive in Human. Host: Rabbit. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OASL, Polyclonal Antibody
Full Product Name
OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14) (PE)
Product Gene Name
anti-OASL antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human OASL.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
514
OMIM
603281
3D Structure
ModBase 3D Structure for Q15646
Immunogen
Synthetic peptide selected from the C-terminal region of human OASL (KLH).
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-OASL antibody

Antibodies; Enzymes; Synthase
Applications Tested/Suitable for anti-OASL antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-OASL antibody
IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-OASL antibody

The anti-OASL C-term Antibody is used in Western blot to detect OASL in HL60 lysate.
Rabbit Anti-OASL Polyclonal Antibody – Cat# MBS6490935

Immunohistochemistry (IHC) of anti-OASL antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-OASL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6490935

Product References and Citations for anti-OASL antibody

1. Hovnanian, A., et al., Genomics 56(3):362-363 (1999). 2. Rebouillat, D., et al., Eur. J. Biochem. 257(2):319-330 (1998). 3. Hartmann, R., et al., Nucleic Acids Res. 26(18):4121-4128 (1998). 4. Lee, J.W., et al., Mol. Endocrinol. 9(2):243-254 (1995). 5. Mackay, V., et al., J. Biol. Chem. 251(12):3716-3719 (1976). 6. Mariko Ishibashi, et al. "Biochemical and Biophysical Research Communications. (E-pub).

Other Notes

Small volumes of anti-OASL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OASL. It may not necessarily be applicable to this product.

NCBI GI #
6226835
NCBI GeneID
8638
NCBI Accession #
Q15646.2
UniProt Primary Accession #
Q15646
UniProt Secondary Accession #
O75686; Q17R95; Q9Y6K6; Q9Y6K7; B2RAZ2; I1YDD2
UniProt Related Accession #
Q15646
NCBI Official Full Name
2'-5'-oligoadenylate synthase-like protein
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase-like
NCBI Official Symbol
OASL
NCBI Official Synonym Symbols
OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
UniProt Protein Name
2'-5'-oligoadenylate synthase-like protein
UniProt Synonym Protein Names
2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL
Protein Family
2'-5'-oligoadenylate synthase-like protein
UniProt Gene Name
OASL
UniProt Synonym Gene Names
TRIP14; 2'-5'-OAS-RP; TR-interacting protein 14; TRIP-14; p59OASL
UniProt Entry Name
OASL_HUMAN
NCBI Protein Information
2'-5'-oligoadenylate synthase-like protein; 2'-5'-OAS-RP; 2'-5'-OAS-related protein; TR-interacting protein 14; thyroid receptor-interacting protein 14; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein

UniProt Comments for OASL

OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1.

Protein type: Nucleolus; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: membrane; cytoplasm; nucleolus; cytosol

Molecular Function: DNA binding; double-stranded RNA binding; thyroid hormone receptor binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: negative regulation of viral genome replication; metabolic process; response to virus; cytokine and chemokine mediated signaling pathway; defense response to virus
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Research Articles on OASL

1. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OASL antibody

 Reference Product  PubMed Publications
 OAS1 antibody  >15 publications with OASL and OAS1
 MX1 antibody  >11 publications with OASL and MX1
 OAS3 antibody  >9 publications with OASL and OAS3
 ISG15 antibody  >9 publications with OASL and ISG15
 IRF7 antibody  >7 publications with OASL and IRF7
 IFIT1 antibody  >6 publications with OASL and IFIT1
 IFI6 antibody  >4 publications with OASL and IFI6
 IFIT2 antibody  >3 publications with OASL and IFIT2
 IFIT3 antibody  >2 publications with OASL and IFIT3
 XAF1 antibody  >1 publications with OASL and XAF1

Pathways associated with anti-OASL antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram

Diseases associated with anti-OASL antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >9 publications with OASL and Liver Diseases
 Nervous System Diseases Antibodies  >7 publications with OASL and Nervous System Diseases
 Inflammation Antibodies  >3 publications with OASL and Inflammation
 Necrosis Antibodies  >2 publications with OASL and Necrosis
 Proteinuria Antibodies  >1 publications with OASL and Proteinuria
 Weight Loss Antibodies  >1 publications with OASL and Weight Loss
 Carcinoma, Hepatocellular Antibodies  >1 publications with OASL and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with OASL and Kidney Diseases
 Muscular Diseases Antibodies  >1 publications with OASL and Muscular Diseases
 Hypertension Antibodies  >1 publications with OASL and Hypertension

Organs/Tissues associated with anti-OASL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with OASL and Blood
 Liver Antibodies  >5 publications with OASL and Liver
 Lung Antibodies  >4 publications with OASL and Lung
 Bone Antibodies  >2 publications with OASL and Bone
 Brain Antibodies  >2 publications with OASL and Brain
 Muscle Antibodies  >1 publications with OASL and Muscle
 Bone Marrow Antibodies  >1 publications with OASL and Bone Marrow
 Thyroid Antibodies  >1 publications with OASL and Thyroid
 Intestine Antibodies  >1 publications with OASL and Intestine
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