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DNPEP Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649178

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. [provided by… More details

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Product Overview

Online Datasheet in PDF
Product Name
DNPEP, Monoclonal Antibody
Full Product Name
DNPEP (ASPEP, DAP, Aspartyl Aminopeptidase)
Product Gene Name
anti-DNPEP antibody
Product Synonym Names
Anti -DNPEP (ASPEP, DAP, Aspartyl Aminopeptidase)
Immunogen Sequence
MQVAMNGKAR KEAVQTAAKE LLKFVNRSPS PFHAVAECRN RLLQAGFSEL KETEKWNIKP ESKYFMTRNS STIIAFAVGG QYVPGNGFSL IGAHTDSPCL RVKRRSRRSQ VGFQQVGVET YGGGIWSTWF DRDLTLAGRV IVKCPTSGRL EQQLVHVERP ILRIPHLAIH LQRNINENFG PNTEMHLVPI LATAIQEELE KGTPEPGPLN AVDERHHSVL MSLLCAHLGL SPKDIVEMEL CLADTQPAVL GGAYD
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2F9-3A7
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human DNPEP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,428 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (220238180..220264730, complement). Location: 2q35
OMIM
611367
3D Structure
ModBase 3D Structure for Q9ULA0
Immunogen
Full length recombinant corresponding to aa1-476 from DNPEP (AAH00653) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-DNPEP antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)
Applications Tested/Suitable for anti-DNPEP antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-DNPEP antibody
Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-DNPEP antibody

Western Blot detection against Immunogen (78.36kD).
Mouse Anti-DNPEP Monoclonal Antibody – Cat# MBS649178

Western Blot (WB) of anti-DNPEP antibody

DNPEP monoclonal antibody Western Blot analysis of DNPEP expression in MCF-7.
Mouse Anti-DNPEP Monoclonal Antibody, Western Blot (WB) – Cat# MBS649178

Immunofluorescence (IF) of anti-DNPEP antibody

Immunofluorescence of monoclonal antibody to DNPEP on MCF-7 cell . [antibody concentration 10ug/ml]
Mouse Anti-DNPEP Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS649178

Other Notes

Small volumes of anti-DNPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNPEP purchase

MBS649178 is an antibody targeting DNPEP. Also known as DNPEP (ASPEP, DAP, Aspartyl Aminopeptidase). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DNPEP. It may not necessarily be applicable to this product.

NCBI GI #
33871413
NCBI GeneID
23549
NCBI Accession #
AAH04854.2
UniProt Primary Accession #
Q9ULA0
UniProt Secondary Accession #
Q9BW44; Q9NUV5
UniProt Related Accession #
Q9ULA0
NCBI Official Full Name
DNPEP protein, partial
NCBI Official Synonym Full Names
aspartyl aminopeptidase
NCBI Official Symbol
DNPEP
NCBI Official Synonym Symbols
DAP; ASPEP
UniProt Protein Name
Aspartyl aminopeptidase
UniProt Gene Name
DNPEP
UniProt Synonym Gene Names
ASPEP; DAP
UniProt Entry Name
DNPEP_HUMAN
NCBI Protein Information
aspartyl aminopeptidase

NCBI Summary for DNPEP

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. [provided by RefSeq, Jul 2008]

UniProt Comments for DNPEP

Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Catalytic activity: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.

Cofactor: Binds 2 zinc ions per subunit.

Enzyme regulation: One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity

By similarity.

Subunit structure: Tetrahedron-shaped homododecamer built from six homodimers. Ref.6

Subcellular location: Cytoplasm.

Tissue specificity: Ubiquitous.

Sequence similarities: Belongs to the peptidase M18 family.

Caution: It is uncertain whether Met-1 or Met-5 is the initiator.

Sequence caution: The sequence BAA92014.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on DNPEP

1. The crystal structure of human DNPEP complexed with zinc and a substrate analogue aspartate-beta-hydroxamate reveals a dodecameric machinery built by domain-swapped dimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DNPEP antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with DNPEP and Nervous System Diseases

Organs/Tissues associated with anti-DNPEP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with DNPEP and Brain
 Bone Antibodies  >1 publications with DNPEP and Bone
 Liver Antibodies  >1 publications with DNPEP and Liver
 Pancreas Antibodies  >1 publications with DNPEP and Pancreas
 Blood Antibodies  >1 publications with DNPEP and Blood
 Eye Antibodies  >1 publications with DNPEP and Eye
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