Rabbit Anti-MXI1 Polyclonal Antibody – Cat# MBS649217

MXI1 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MXI1 antibody detected the MXI1 protein (arrow).

MXI1 Antibody – Rabbit Polyclonal

Name: MXI1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649217
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649217

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MXI1, Polyclonal Antibody

Full Product Name

MXI1, ID (MXI1, BHLHC11, Max-interacting protein 1, Class C basic helix-loop-helix protein 11)

Product Gene Name

anti-MXI1 antibody

Product Synonym Names

Anti -MXI1, ID (MXI1, BHLHC11, Max-interacting protein 1, Class C basic helix-loop-helix protein 11)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

26,062 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (111967288..112047123). Location: 10q24-q25

OMIM

176807

3D Structure

ModBase 3D Structure for P50539

Immunogen

MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the Central region of human MXI1.

Product Categories/Family for anti-MXI1 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-MXI1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-MXI1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-MXI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MXI1 purchase

MBS649217 is an antibody targeting MXI1. Also known as MXI1, ID (MXI1, BHLHC11, Max-interacting protein 1, Class C basic helix-loop-helix protein 11). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MXI1. It may not necessarily be applicable to this product.

NCBI GI #

57242782

NCBI GeneID

4601

NCBI Accession #

NP_005953.4

UniProt Primary Accession #

P50539

UniProt Secondary Accession #

Q15887; Q6FHW2; Q96E53; B1ANN7; D3DR25; D3DRA9

UniProt Related Accession #

P50539

GenBank Nucleotide #

NM_005962.4

NCBI Official Full Name

max-interacting protein 1 isoform a

NCBI Official Synonym Full Names

MAX interactor 1, dimerization protein

NCBI Official Symbol

MXI1

NCBI Official Synonym Symbols

MXI; MAD2; MXD2; bHLHc11

UniProt Protein Name

Max-interacting protein 1

UniProt Synonym Protein Names

Class C basic helix-loop-helix protein 11

Protein Family

Max-interacting protein

UniProt Gene Name

MXI1

UniProt Synonym Gene Names

BHLHC11; Max interactor 1; bHLHc11

UniProt Entry Name

MXI1_HUMAN

NCBI Protein Information

max-interacting protein 1; MAX dimerization protein 2; Max-related transcription factor; class C basic helix-loop-helix protein 11

UniProt Comments for MXI1

Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Subunit structure: Interacts with SMC3

By similarity. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17

By similarity.

Subcellular location: Nucleus.

Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Involvement in disease: Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

Research Articles on MXI1

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MXI1 antibody

Reference Product	PubMed Publications
MYC antibody	>111 publications with MXI1 and MYC
MAX antibody	>72 publications with MXI1 and MAX
SIN3A antibody	>3 publications with MXI1 and SIN3A
SMC3 antibody	>1 publications with MXI1 and SMC3
SIN3B antibody	>1 publications with MXI1 and SIN3B

Diseases associated with anti-MXI1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>74 publications with MXI1 and Neoplasms
Carcinoma Antibodies	>20 publications with MXI1 and Carcinoma
Prostatic Neoplasms Antibodies	>14 publications with MXI1 and Prostatic Neoplasms
Adenocarcinoma Antibodies	>12 publications with MXI1 and Adenocarcinoma
Kidney Diseases Antibodies	>9 publications with MXI1 and Kidney Diseases
Breast Neoplasms Antibodies	>5 publications with MXI1 and Breast Neoplasms
Lung Neoplasms Antibodies	>5 publications with MXI1 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>4 publications with MXI1 and Neoplasms, Experimental
Inflammation Antibodies	>3 publications with MXI1 and Inflammation
Carcinoma, Squamous Cell Antibodies	>3 publications with MXI1 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-MXI1 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>15 publications with MXI1 and Prostate
Blood Antibodies	>15 publications with MXI1 and Blood
Kidney Antibodies	>12 publications with MXI1 and Kidney
Skin Antibodies	>11 publications with MXI1 and Skin
Bone Antibodies	>8 publications with MXI1 and Bone
Brain Antibodies	>8 publications with MXI1 and Brain
Bone Marrow Antibodies	>5 publications with MXI1 and Bone Marrow
Lung Antibodies	>5 publications with MXI1 and Lung
Connective Tissue Antibodies	>4 publications with MXI1 and Connective Tissue
Lymph Node Antibodies	>2 publications with MXI1 and Lymph Node