Rabbit Anti-SFTPA2B Polyclonal Antibody – Cat# MBS649245

SFTPA2B Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SFTPA2B antibody detected the SFTPA2B protein (arrow).

SFTPA2B Antibody – Rabbit Polyclonal

Name: SFTPA2B Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649245
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649245

This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SFTPA2B, Polyclonal Antibody

Full Product Name

SFTPA2B, CT (SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B, Pulmonary surfactant-associated protein A2, 35kD pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5)

Product Gene Name

anti-SFTPA2B antibody

Product Synonym Names

Anti -SFTPA2B, CT (SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B, Pulmonary surfactant-associated protein A2, 35kD pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

26,182 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (81315622..81320163, complement). Location: 10q22.3

OMIM

178500

3D Structure

ModBase 3D Structure for Q8IWL1

Immunogen

SFTPA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the C-terminal region of human SFTPA2B.

Product Categories/Family for anti-SFTPA2B antibody

Antibodies; Abs to Pulmonary Proteins

Applications Tested/Suitable for anti-SFTPA2B antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SFTPA2B antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SFTPA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFTPA2B purchase

MBS649245 is an antibody targeting SFTPA2B. Also known as SFTPA2B, CT (SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B, Pulmonary surfactant-associated protein A2, 35kD pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SFTPA2B. It may not necessarily be applicable to this product.

NCBI GI #

141797003

NCBI GeneID

6436

NCBI Accession #

AAI39728.1

UniProt Primary Accession #

Q8IWL1

UniProt Secondary Accession #

P07714; Q14DV3; Q5RIR8; A4QPA7; B2RXI6; B2RXK9; C9J9I7; E3VLC6; E3VLC7; E3VLC8; E3VLC9

UniProt Related Accession #

Q8IWL1

NCBI Official Full Name

Surfactant protein A2B

NCBI Official Synonym Full Names

surfactant protein A2B

NCBI Official Symbol

SFTPA2B

NCBI Official Synonym Symbols

SP-2A; SP-A1; SP-A2; SPAII; SFTPA2; AC068139.3

UniProt Protein Name

Pulmonary surfactant-associated protein A2

UniProt Synonym Protein Names

35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-5

UniProt Gene Name

SFTPA2

UniProt Synonym Gene Names

COLEC5; PSAP; SFTP1; SFTPA; SFTPA2B; PSP-A; PSPA; SP-A; SP-A2

UniProt Entry Name

SFPA2_HUMAN

NCBI Protein Information

surfactant protein A2B; SP-2A beta; SP-A1 beta; surfactant pulmonary associated protein A2; surfactant, pulmonary-associated protein A2B

NCBI Summary for SFTPA2B

DISCONTINUED: This record has been withdrawn by the HUGO Gene Nomenclature Committee (HGNC), and it has been determined that the sequence is redundant with SFTPA2 (GeneID:729238) in the GRCh37.1 reference assembly.

UniProt Comments for SFTPA2B

Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Subunit structure: Oligomeric complex of 6 set of homotrimers.

Subcellular location: Secreted › extracellular space › extracellular matrix. Secreted › extracellular space › surface film.

Polymorphism: At least 6 alleles of SFTPA2 are known: 1A, 1A0, 1A1, 1A2, 1A3 and 1A4. The sequence shown is that of allele 1A0.

Involvement in disease: Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Miscellaneous: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Sequence similarities: Belongs to the SFTPA family.Contains 1 C-type lectin domain.Contains 1 collagen-like domain.

Research Articles on SFTPA2B

1. The 19Ala allele of SP-A1 gene and the 223Gln allele of SP-A2 gene are risk factors for recurrent urinary tract infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SFTPA2B antibody

Reference Product	PubMed Publications
SFTPA1 antibody	>1 publications with SFTPA2B and SFTPA1

Diseases associated with anti-SFTPA2B antibody

Disease Name	Pubmed Publications
Arrhythmias, Cardiac Antibodies	>1 publications with SFTPA2B and Arrhythmias, Cardiac
Cardiovascular Diseases Antibodies	>1 publications with SFTPA2B and Cardiovascular Diseases
Cardiomegaly Antibodies	>1 publications with SFTPA2B and Cardiomegaly