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PAPPA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649288

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. More details

$835 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PAPPA2, Polyclonal Antibody
Full Product Name
PAPPA2, NT (Pappalysin-2, Pregnancy-associated Plasma Protein A2, PAPP-A2, Pregnancy-associated Plasma Protein E1, PAPP-E, PLAC3)
Product Gene Name
anti-PAPPA2 antibody
Product Synonym Names
Anti -PAPPA2, NT (Pappalysin-2, Pregnancy-associated Plasma Protein A2, PAPP-A2, Pregnancy-associated Plasma Protein E1, PAPP-E, PLAC3)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PAPPA2. Species sequence homology: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
198,539 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (176432307..176814737). Location: 1q23-q25
3D Structure
ModBase 3D Structure for Q9BXP8
Immunogen
Synthetic peptide corresponding to 15aa from human PLAC3 at N-terminus.

Product Categories/Family for anti-PAPPA2 antibody

Antibodies; Abs to Hormones; Steroids
Applications Tested/Suitable for anti-PAPPA2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PAPPA2 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-PAPPA2 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PAPPA2 Polyclonal Antibody – Cat# MBS649288

Immunohistochemistry (IHC) of anti-PAPPA2 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PAPPA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649288

Other Notes

Small volumes of anti-PAPPA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAPPA2 purchase

MBS649288 is an antibody targeting PAPPA2. Also known as PAPPA2, NT (Pappalysin-2, Pregnancy-associated Plasma Protein A2, PAPP-A2, Pregnancy-associated Plasma Protein E1, PAPP-E, PLAC3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPPA2. It may not necessarily be applicable to this product.

NCBI GI #
116174738
NCBI GeneID
60676
NCBI Accession #
NP_064714.2
UniProt Primary Accession #
Q9BXP8
UniProt Secondary Accession #
Q96PH7; Q96PH8; Q9H4C9; A9Z1Y8
UniProt Related Accession #
Q9BXP8
GenBank Nucleotide #
NM_020318.2
NCBI Official Full Name
pappalysin-2 isoform 1
NCBI Official Synonym Full Names
pappalysin 2
NCBI Official Symbol
PAPPA2
NCBI Official Synonym Symbols
PAPPE; PLAC3; PAPP-E; PAPP-A2
UniProt Protein Name
Pappalysin-2
UniProt Synonym Protein Names
Pregnancy-associated plasma protein A2; PAPP-A2; Pregnancy-associated plasma protein E1
Protein Family
Pappalysin
UniProt Gene Name
PAPPA2
UniProt Synonym Gene Names
PLAC3; PAPP-A2; PAPP-E
UniProt Entry Name
PAPP2_HUMAN
NCBI Protein Information
pappalysin-2; placenta-specific 3; pregnancy-associated plasma protein E1; pregnancy-associated plasma preproprotein-A2

NCBI Summary for PAPPA2

This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
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UniProt Comments for PAPPA2

Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Ref.1

Catalytic activity: Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subunit structure: Monomer.

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. Ref.1 Ref.2

Sequence similarities: Belongs to the peptidase M43B family.Contains 5 Sushi (CCP/SCR) domains.

Sequence caution: The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on PAPPA2

1. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAPPA2 antibody

 Reference Product  PubMed Publications
 IGFBP5 antibody  >7 publications with PAPPA2 and IGFBP5
 IGFBP4 antibody  >2 publications with PAPPA2 and IGFBP4

Pathways associated with anti-PAPPA2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with anti-PAPPA2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with PAPPA2 and Necrosis
 Myocardial Infarction Antibodies  >1 publications with PAPPA2 and Myocardial Infarction
 Anemia Antibodies  >1 publications with PAPPA2 and Anemia
 Pain Antibodies  >1 publications with PAPPA2 and Pain
 Cardiovascular Diseases Antibodies  >1 publications with PAPPA2 and Cardiovascular Diseases

Organs/Tissues associated with anti-PAPPA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >11 publications with PAPPA2 and Placenta
 Bone Antibodies  >3 publications with PAPPA2 and Bone
 Liver Antibodies  >2 publications with PAPPA2 and Liver
 Heart Antibodies  >2 publications with PAPPA2 and Heart
 Brain Antibodies  >2 publications with PAPPA2 and Brain
 Uterus Antibodies  >2 publications with PAPPA2 and Uterus
 Muscle Antibodies  >1 publications with PAPPA2 and Muscle
 Lung Antibodies  >1 publications with PAPPA2 and Lung
 Pancreas Antibodies  >1 publications with PAPPA2 and Pancreas
 Kidney Antibodies  >1 publications with PAPPA2 and Kidney
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