KLC1 Antibody – Mouse Polyclonal

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Subunit structure: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9

By similarity. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections

By similarity. Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell. Ref.14

Subcellular location: Cytoplasm › cytoskeleton

Probable.

Tissue specificity: Found in a variety of tissues. Mostly abundant in brain and spine.

Post-translational modification: Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631. Ref.12

Sequence similarities: Belongs to the kinesin light chain family.Contains 6 TPR repeats.

Caution: It is uncertain whether Met-1 or Met-5 is the initiator.

Sequence caution: The sequence AAA16576.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF72543.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO62549.1 differs from that shown. Reason: Erroneous initiation. The sequence DAA01265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01266.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01289.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01295.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence DAA01297.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.