FKBP8 Antibody – Mouse Polyclonal

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Ref.1 Ref.10 Ref.12

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Ref.11

Cofactor: Calcium. Ref.11

Subunit structure: Homomultimers or heteromultimers

Potential. Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Ref.1 Ref.3 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17

Subcellular location: Isoform 1: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Ref.1 Ref.3 Ref.10. Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Ref.1 Ref.3 Ref.10.

Tissue specificity: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. Ref.3

Miscellaneous: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.

Sequence similarities: Contains 1 PPIase FKBP-type domain.Contains 3 TPR repeats.

Caution: It is uncertain whether Met-1 or Met-58 is the initiator.

Sequence caution: The sequence AAB00102.1 differs from that shown. Reason: The first part of the cDNA maps to the same locus, but in opposite orientation.The sequence AAH09966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAD98028.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.